Systematic review and Meta-analysis of risk prediction models for anastomotic leakage after radical colorectal cancer surgery
10.3760/cma.j.cn115682-20241212-06816
- VernacularTitle:结直肠癌根治术后吻合口瘘发生风险预测模型的系统评价与Meta分析
- Author:
Li YUAN
1
;
Jiayi SU
;
Xia LI
;
Aixin ZHOU
;
Hua ZHANG
Author Information
1. 重庆医科大学附属第一医院护理部，重庆 400042
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Anastomotic leakage;
Risk prediction model;
Systematic review;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2025;31(18):2442-2451
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate existing risk prediction models for anastomotic leakage after colorectal cancer surgery, and to provide theoretical support for clinical model selection and the future development of improved models.Methods:A comprehensive search was conducted across databases including China National Knowledge Infrastructure, Wanfang Data, VIP, CINAHL, PubMed, Embase, Web of Science, and the Cochrane Library from inception to December 31, 2024. Two researchers independently screened the literature and extracted relevant data. The prediction model risk of bias assessment tool was used to evaluate the risk of bias and applicability of included studies. A Meta-analysis of common predictive factors was performed using Stata 18.0.Results:A total of 28 studies were included. The identified predictive factors for anastomotic leakage after radical colorectal cancer surgery included preoperative diabetes, tumor size, preoperative chemoradiotherapy, tumor distance from the anal verge, body mass index, combined organ resection, Nutrition Risk Screening 2002 (NRS-2002) score, diverting stoma, preoperative bowel obstruction, and operative time.Conclusions:Future studies may reference the predictive factors summarized in this study and select appropriate methods in combination with clinical scenarios to develop and validate more effective risk prediction models for anastomotic leakage.
