The relationship between CT lung volume parameters and pulmonary function grade in patients with idiopathic pulmonary fibrosis and its prediction of acute exacerbation
10.3969/j.issn.1002-1671.2025.07.030
- VernacularTitle:CT肺容积参数与特发性肺纤维化患者肺功能分级的关系及其对急性加重期的预测
- Author:
Yafeng LIU
1
;
Chunliang YAN
;
Shaofei LI
;
Xiyan REN
;
Huijuan ZHANG
;
Chunting TAN
Author Information
1. 北京航天总医院呼吸与危重症医学科,北京 100076
- Publication Type:Journal Article
- Keywords:
CT lung volume parameters;
idiopathic pulmo-nary fibrosis;
pulmonary function;
acute exacerbation
- From:
Journal of Practical Radiology
2025;41(7):1215-1219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CT lung volume parameters(CT-LVP)and pulmonary function grade in patients with idiopathic pulmonary fibrosis(IPF)and its prediction of acute exacerbation.Methods A total of 204 patients with IPF were selected and divided into mild group(67 cases),moderate group(72 cases)and severe group(65 cases)according to the semi-quantitative scoring method of high-resolution computed tomography(HRCT).The correlation between CT-LVP and pul-monary function parameters(PFP)were analyzed.The predictive value of CT-LVP for acute exacerbation in severe IPF was ana-lyzed.Results The whole lung volume(WLV),normal lung volume(NLV)and normal lung volume percentage(NLV%)in severe group were lower than those in mild and moderate groups,whereas interstitial lung disease volume(ILDV)and interstitial lung disease volume percentage(ILDV%)were higher than those in mild and moderate groups,with statistical significance(P<0.05).WLV,NLV,ILDV,NLV%,ILDV%showed strong correlations with forced expiratory volume in 1 second percentage(FEV1%),forced expiratory volume in 1 second to forced vital capacity ratio(FEV1/FVC),diffusing capacity of the lung for carbon monoxide percent-age(DLCO%),and residual volume to total lung capacity ratio(RV/TLC).Receiver operating characteristic(ROC)curve analysis showed that the combination of WLV,NLV,ILDV,NLV%and ILDV%had higher accuracy in predicting acute exacerbation,area under the curve(AUC)>0.75(P<0.05).Conclusion CT-LVP is closely related to PFP,and the accuracy of CT-LVP combination in predicting acute exacerbation is high,which provides a theoretical basis for preventing acute exacerbation of IPF.
