A study of the correlation between thalamic metabolites changes and spinal cord injury in cervical spondylotic myelopathy
10.3969/j.issn.1002-1671.2025.07.002
- VernacularTitle:脊髓型颈椎病丘脑代谢产物变化与脊髓损伤的相关性研究
- Author:
Yujin ZHANG
1
;
Baogen ZHAO
1
;
Tong ZHANG
1
;
Ting GAO
1
;
Ning WANG
1
;
Yong WANG
1
;
Li ZHANG
1
Author Information
1. 河北医科大学第一医院放射与核医学科,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
cervical spondylotic myelopathy;
diffusion tensor imaging;
magnetic resonance spectroscopy
- From:
Journal of Practical Radiology
2025;41(7):1085-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in metabolites detected by magnetic resonance spectroscopy(MRS)in the dorsal thalamus of patients with cervical spondylotic myelopathy(CSM)and to analyze their correlation with spinal cord injury based on diffusion tensor imaging(DTI).Methods A total of 93 patients with CSM(patient group)and 67 healthy volunteers(control group)were selected.DTI parameters of the spinal cord and MRS parameters of the thalamus were compared between the two groups.Correlation analysis were performed among clinical features,conventional imaging features,DTI parameters,and metabolites in CSM patients.Multifacto-rial linear regression equations for thalamic metabolites based on the aforementioned characteristics were established.Results The fractional anisotropy(FA)value was significantly lower in the patient group than in the control group(P=0.005,t=2.874).The N-acetyl aspartate/creatine(NAA/Cr)ratio(P<0.001,Z=-5.922),choline/Cr(Cho/Cr)ratio(P<0.001,Z=-6.857),and myo-inositol/Cr(MI/Cr)ratio(P<0.001,Z=-6.573)were significantly lower in the patient group than in the control group.The NAA/Cr ratio(r=0.444,P<0.001),Cho/Cr ratio(r=0.308,P=0.003),and MI/Cr ratio(r=-0.489,P<0.001)were corre-lated with the FA value in the patient group.There was a correlation between the NAA/Cr ratio and the duration(r=-0.365,P<0.001).Multifactorial linear regression equations for each metabolites in the thalamus:NAA/Cr=0.833+1.520×FA-0.007×duration;Cho/Cr=0.209+0.774×FA;MI/Cr=1.566-1.722×FA+0.008×modified Japanese Orthopaedic Association(mJOA)score;glu-tamate/Cr(Glx/Cr)=0.942+0.009×duration.Conclusion CSM patients exhibit metabolic alterations in the dorsal thalamus,which are linearly correlated with the degree of spinal cord injury.
