Prevalence and influencing factors of psychiatric comorbidities in patients with refractory epilepsy: a Meta-analysis
10.3760/cma.j.cn115682-20241025-05833
- VernacularTitle:难治性癫痫患者精神共患病发生率及影响因素的Meta分析
- Author:
Wenshuang WANG
1
;
Jinglian LI
;
Qian LI
;
Jingjing GU
;
Liyun ZHONG
;
Kai ZHANG
Author Information
1. 首都医科大学附属北京天坛医院护理部，北京 100070
- Publication Type:Journal Article
- Keywords:
Drug resistant epilepsy;
Psychiatric comorbidities;
Prevalence;
Influencing factors;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2025;31(17):2275-2282
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically analyze the prevalence and influencing factors of psychiatric comorbidities in refractory epilepsy (RE) .Methods:The literature on the prevalence and/or influencing factors of psychiatric comorbidities in adults with RE was electronically searched in China National Knowledge Infrastructure, WanFang Data, VIP, China Biomedical Database, PubMed, Web of Science, Embase, CINAHL, OVID, UpToDate, and Cochrane Library. The search period was from the establishment of the database to July 31, 2024. Two researchers independently conducted literature screening, quality assessment and data extraction, and used RevMan 5.4 for Meta-analysis.Results:A total of 11 papers were included, with a total sample size of 1 953 cases, with a prevalence of 52.00% (cross sectional studies) and 53.00% (cohort studies) . Gender [ OR=4.76, 95% CI (3.69, 6.15) ] , epilepsy disease perception [ OR=1.10, 95% CI (1.01, 1.19) ] , seizure type [ OR=1.63, 95% CI (1.23, 2.15) ] , seizure frequency [ OR=1.54, 95% CI (1.04, 2.29) ] , epileptogenic foci location [ OR=2.72, 95% CI (1.69, 4.37) ] , disease duration [ OR=1.76, 95% CI (1.39, 2.24) ] , and medication [ OR=3.26, 95% CI (2.09, 5.08) ] were the influencing factors of psychiatric comorbidity in RE. Conclusions:The prevalence of psychiatric comorbidities in patients with RE is high, and studies of influencing factors lack specificity. Clinical monitoring of this population should be strengthened, and relevant influencing factors should be comprehensively analyzed to provide intervention targets for early preventive management and to safeguard the long-term management of patients with epilepsy.
