Expression and Clinical Significance of S100A7,IGF-1 and RAGE in Endometrial Carcinoma Type Ⅰ
10.11969/j.issn.1673-548X.2025.06.016
- VernacularTitle:S100A7、IGF-1、RAGE 在Ⅰ型子宫内膜癌组织中的表达及临床意义
- Author:
Pei ZHANG
1
;
Wei DING
;
Xi-aoyuan LU
Author Information
1. 221004 徐州医科大学研究生院
- Publication Type:Journal Article
- Keywords:
Type Ⅰ endometrial carcinoma;
S100A7;
IGF-1;
RAGE;
Clinicopathological characteristics;
Prognosis
- From:
Journal of Medical Research
2025;54(6):87-91,86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of S100 cabinding protein A7(S100A7),insulin-like growth factor-1(IGF-1),and receptor for advanced glycation end products(RAGE)in type Ⅰ endometrial carcinoma(EC).Methods 60 patients with type 1 EC and 30 normal endometrial tissues were selected and analyzed by real-time fluorescent quantita-tive polymerase chain reaction(RT-qPCR).RT-qPCR was used to detect the expression of S100A7,IGF-1 and RAGE mRNA in dif-ferent endometrial tissues.The protein expression of S100A7,IGF-1 and RAGE in 107 type Ⅰ EC tissues,24 cases endometrial tissues with atypical hyperplasia and 30 normal endometrial tissues were detected by immunohistochemical method.The correlation between the three and the clinicopathological characteristics of the patients was analyzed.Kaplan-Meier method was used to draw the survival curve,and COX regression analysis was performed to analyze the factors affecting the survival and prognosis of patients.Results The expres-sions of S100A7,IGF-1 and RAGE mRNA in EC tissues were increased compared with normal endometrial tissues(P＜0.05).The positive rates of S100A7,IGF-1 and RAGE proteins increased with the progression of endometrial lesions,and there was a significant positive correlation among them(P＜0.05).For different International Federation of Gynecology and Obstetrics(FIGO)staging,pres-ence or absence of lymph node metastasis,and degree of tissue differentiation in type Ⅰ EC,The positive rates of S100A7,IGF-1 and RAGE were different(P＜0.05).Kaplan-Meier survival analysis showed that the average survival time of patients with positive expres-sion of S100A7,IGF-1 and RAGE was lower.COX regression analysis showed that lymph node metastasis,high expression of S100A7,IGF-1 and RAGE were independent risk factors for prognosis of patients with type Ⅰ EC.Conclusion The increased expression levels of S100A7,IGF-1 and RAGE in type Ⅰ EC are closely associated with the emergence,progress and bleak prognosis of EC.
