Study of β-amyloid protein deposition in brain regions on progression from mild cognitive impairment to Alzheimer's disease
10.3760/cma.j.cn112338-20250201-00066
- VernacularTitle:β-淀粉样蛋白沉积脑区对轻度认知障碍向阿尔茨海默病转归的影响
- Author:
Yanxia WANG
1
;
Yonghua MA
1
;
Xinyu YANG
1
;
Guiya GUO
1
;
Wangchen SONG
1
;
Aimin WANG
1
;
Suzhen WANG
1
;
Fuyan SHI
1
Author Information
1. 山东第二医科大学公共卫生学院卫生统计学教研室，潍坊 261053
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
β -amyloid protein;
Multivariable longitudinal data joint model;
Penalized generalized estimating equation;
Mixed effects r
- From:
Chinese Journal of Epidemiology
2025;46(9):1660-1666
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the key β-amyloid protein (Aβ) deposition in brain regions affecting the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD).Methods:Based on the positron emission tomography data of Aβ in the Alzheimer's disease neuroimaging initiative database, the penalized generalized estimating equation (PGEE) and the mixed effects regression forest algorithm (MERF) were used to conduct dimensionality reduction analysis on 164 brain regions with Aβ deposition. Additionally, a multivariate longitudinal data joint model was used to screen the key Aβ deposition brain regions that influence the progression from MCI to AD.Results:Five key brain regions were commonly screened out by the PGEE and MERF models, they were the right prefrontal orbital cortex, the left superior temporal sulcus shore cortex, the right medial orbitofrontal cortex, the left putamen, and the right transverse temporal cortex, respectively. The results of the multivariate longitudinal data joint model based on these 5 Aβ deposition brain regions showed that, except the left superior temporal sulcus shore cortex, the longitudinal change trajectories of the other 4 Aβ deposition brain regions all affected the progression from MCI to AD ( P<0.05). Conclusion:The Aβ deposition in the right prefrontal orbital cortex, right medial orbitofrontal cortex, left putamen and right transverse temporal cortex affect the progression from MCI to AD.
