Differences of local brain activity in first-episode drug-na?ve depressive patients with and without suicidal ideation during resting-state
10.3969/j.issn.1002-1671.2025.07.003
- VernacularTitle:伴与不伴自杀意念首发未治疗抑郁患者静息态局部脑活动差异
- Author:
Hua XIAO
1
;
Limin YAO
;
Qian ZHAO
;
Yangyang XU
;
Shan XIE
;
Hongquan LU
;
Qin JIANG
;
Kaitang ZHU
Author Information
1. 南京市江宁区第二人民医院心理科,江苏 南京 211103
- Publication Type:Journal Article
- Keywords:
major depressive disorder;
suicidal ideation;
resting-state functional magnetic resonance imaging;
Hamilton depression scale;
Beck scale for suicide ideation
- From:
Journal of Practical Radiology
2025;41(7):1089-1093
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the differences of brain activity between first-episode untreated depressive patients with and without suicidal ideation(SI),and its correlations with clinical characteristics.Methods A total of 40 major depressive disorder(MDD)patients with SI(MDD+SI group),40 patients without SI MDD(MDD+NSI group),and 40 healthy controls(HC)(HC group)were enrolled.The 17-item Hamilton depression scale(HAMD-17)and Beck scale for suicide ideation(BSI)were used to assess the severity of depression and SI,respectively.MRI data were collected.The values of fractional amplitude of low-frequency fluctuation(fALFF)were calculated.Results(1)Compared with the HC group,the MDD+NSI group showed decreases in the fALFF val-ues of the default network and attention network.The fALFF values of the attention network in the MDD+SI group showed decreases.Compared with the MDD+NSI group,the MDD+SI group showed decreases in the fALFF values of the attention network.(2)The fALFF values in the left middle frontal gyrus were negatively correlated with the total score of HAMD-17(r=-0.55;P<0.001)in the MDD+NSI group,while the fALFF values in the left middle frontal gyrus were negatively correlated with the total score of HAMD-17(r=-0.53;P<0.001)and the total score of BSI(r=-0.51;P<0.001)in the MDD+SI group.(3)The optimal critical value of fALFF value in left middle frontal gyrus for predicting SI occurrence in MDD patients was-0.039,area under the curve(AUC)was 0.76,sensitivity was 0.63,and specificity was 0.80.Conclusion The decreased local activity intensity in the left middle frontal gyrus of the brain might be the central mechanism for the occurrence of SI in MDD patients.In addition,the left middle frontal gyrus might have certain value in identifying SI and predicting the severity of SI.
