Short-term efficacy and prognostic factors of donafenib combined with transcatheter arterial chemoembolization in the treatment of spontaneously ruptured hepatocellular carcinoma
10.3969/j.issn.1002-1671.2025.07.026
- VernacularTitle:多纳非尼联合肝动脉化疗栓塞术治疗肝癌破裂出血短期疗效及预后因素分析
- Author:
Qi ZHANG
1
;
Hezi QING
;
Zhenwu LEI
Author Information
1. 青海大学附属医院介入科,青海 西宁 810000
- Publication Type:Journal Article
- Keywords:
donafenib;
transcatheter arterial chemoembolization;
spontaneously ruptured hepatocellular carcinoma;
prognostic factors
- From:
Journal of Practical Radiology
2025;41(7):1198-1202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short-term efficacy and prognostic factors of donafenib combined with transcatheter arterial chemoembolization(TACE)in the treatment of spontaneously ruptured hepatocellular carcinoma.Methods A retrospective analysis was conducted on the data of patients diagnosed with spontaneously ruptured hepatocellular carcinoma.According to the treatment meth-ods,patients were categorized into simple group(TACE)and combined group(donafenib combined with TACE).Median progres-sion-free survival(mPFS),objective remission rate(ORR),disease control rate(DCR),and median overall survival(mOS)were calculated,and treatment-related adverse events were counted.Finally,prognostic survival factors were analyzed by Cox regression.Results The mPFS for the simple group was 4.6 months,compared to 13.6 months for the combined group(χ2=9.081,P=0.003).Similarly,the mOS for the simple group was 7.6 months,compared to 17.4 months for the combined group(χ2=6.351,P=0.012).Both mPFS and mOS were significantly lower in the simple group than those in the combined group.The ORR of 25.7%and DCR of 57.1%in the simple group were significantly lower than the ORR of 55.6%and DCR of 81.5%in the combined group,and the difference between the two groups was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of rebleeding,abdominal pain and fever between the two groups(P>0.05).Additionally,age,portal vein tumor thrombus(PVTT),Child-Pugh grade,tumor diameter,and total biliru-bin(TBIL)were identified as prognostic factors(P<0.05).Conclusion Donafenib combined with TACE is an effective and safe treatment option for spontaneously ruptured hepatocellular carcinoma.Furthermore,factors such as age,PVTT,Child-Pugh grade,tumor diameter,and TBIL serve as prognostic indicators for spontaneously ruptured hepatocellular carcinoma.
