The Synergistic Effect of Astaxanthin and Curcumin on the Outcome of IVF-ET Treatment in Patients with Poor Ovarian Response
10.3969/j.issn.1003-6946.2025.09.016
- VernacularTitle:虾青素和姜黄素协同对卵巢低反应患者体外受精-胚胎移植治疗结局的影响
- Author:
Dongmei TIAN
1
;
Shaomi ZHU
;
Wei WANG
;
Ping HUANG
;
Mengyue FENG
;
Xin LIANG
Author Information
1. 成都中医药大学附属生殖妇幼医院生殖中心,四川成都 610041
- Publication Type:Journal Article
- Keywords:
Astaxanthin;
Curcumin;
Poor ovarian response;
Assisted reproductive technology;
Pregnancy outcome
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(9):771-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the synergistic effect of astaxanthin and curcumin on assisted reproduc-tive technology(ART)outcomes in patients with poor ovarian response(POR).Methods:A prospective cohort study was conducted,involving 123 POR patients enrolled at the Reproductive & Women-Children Hospital,Chengdu University of Traditional Chinese Medicine between March 6,2023 to May 1,2024.According to patient preference,participants were divided into the treatment group(41 cases)and the control group(82 cases)at a ratio of 1∶2.The treatment group took astaxanthin and turmeric compound tablets orally for 60 to 90 days before ovulation induction treatment.The ovulation induction parameters and pregnancy outcomes were compared between the two groups,and a self-controlled analysis was conducted within the treatment group.Results:During the observation period,5 and 10 participants withdrew from the treatment and control groups,respectively,resul-ting in 108 patients included in the final analysis.There were no statistically significant differences between the two group in terms of endometrial thickness on the day of human chorionic gonadotropin(HCG),number of oocytes retrieved,oocyte maturation rate,normal fertilization rate,high-quality embryo rate,or cycle cancellation rate(P＞0.05).However,the treatment group demonstrated significantly higher clinical pregnancy rate(61.54％vs.28.57％),fresh embryo implantation rate(40.91％vs.18.97％),and cumulative clinical pregnancy rate(65.38％vs.33.33％)(P＜0.05).The early miscarriage rate was observed with no significant difference between groups(12.5％vs.10.0％)(P＞0.05).Furthermore,after treatment,basal FSH(bFSH),basal E2(bE2),antral follicles count(AFC),anti-Müllerian hormone(AMH),and the number of oocytes retrieved within the treatment group were significantly improved compared with those before treatment(P＜0.05).Conclusions:Pretreatment with astaxanthin and turmeric compound tablets in POR patients did not significantly improve the ovulation induction re-sponse,but was associated with increased fresh embryo clinical pregnancy rate,implantation rate,and cumulative pregnancy rate.The underlying mechanism may involve modulation of basal endocrine profiles and improvement of ovarian reserve function,though further investigation is required to elucidate precise pathways.
