Research advances in tissue engineering bionic periosteum for bone repair
10.3760/cma.j.cn121113-20250307-00234
- VernacularTitle:组织工程仿生骨膜在骨修复中的应用研究进展
- Author:
Hao WEI
1
;
Kaiyong CAI
1
;
Yan HU
1
Author Information
1. 重庆大学生物工程学院，生物流变科学与技术教育部重点实验室，重庆 400044
- Publication Type:Journal Article
- Keywords:
Periosteum;
Tissue engineering;
Bone remodeling;
Review
- From:
Chinese Journal of Orthopaedics
2025;45(20):1341-1347
- CountryChina
- Language:Chinese
-
Abstract:
Functionalized tissue-engineered biomimetic periosteum has similar functions and structures to natural periosteum, can enhance bone regeneration function, and is expected to become a direct substitute for natural periosteum. Inorganic materials such as hydroxyapatite, tricalcium phosphate, and bioactive glass graphene oxide were prepared into nanoparticles, nanowires, microspheres, etc., and combined with natural materials to introduce them into tissue-engineered periosteum, which effectively improved the mechanical properties of natural materials and delayed the degradation of implants. In addition, elements such as calcium and phosphorus in inorganic materials have chemical similarities to natural bones and can mediate the microenvironment to promote bone and blood vessel regeneration, thereby facilitating bone healing. The construction of vascularized and neuralized tissue-engineered periosteum not only promotes the framework of bone regeneration but also provides support for blood vessels and nerves, thereby accelerating the bone healing process and enhancing the bone tissue repair capacity. The composite scaffold system carrying fibroblast growth factor with gelatin hydrogel as the carrier has demonstrated excellent dual effects of promoting angiogenesis and bone repair.
