Clinical application and research advances of bone marrow enrichment bone repair technology
10.3760/cma.j.cn121113-20250219-00152
- VernacularTitle:骨髓富集骨修复技术的临床应用与研究进展
- Author:
Junchao XING
1
;
Shihao HE
1
;
Dong SUN
1
;
Fei LUO
1
Author Information
1. 陆军军医大学第一附属医院骨科，重庆 400038
- Publication Type:Journal Article
- Keywords:
Bone transplantation;
Wounds and injuries;
Spinal fusion;
Bone defects;
Bone marrow concentration
- From:
Chinese Journal of Orthopaedics
2025;45(20):1335-1340
- CountryChina
- Language:Chinese
-
Abstract:
The clinical demand for bone graft materials is substantial, but materials other than autologous bone generally suffer from insufficient osteogenic activity. Bone marrow concentration-based bone repair technology addresses this by concentrating stem cells and cytokines from autologous bone marrow onto scaffold materials (such as allograft bone, demineralized bone matrix, tricalcium phosphate, hydroxyapatite, etc.) to construct highly active bone repair materials, effectively enhancing their osteogenic efficacy. Current evidence suggests that this technology can be used in the surgical treatment of bone ununion, bone defects, benign bone tumors and tumor-like lesions, femoral head necrosis, and spinal fusion. The core steps of this technology include bone marrow aspiration, bone marrow concentration, and bone grafting. Among these, bone marrow aspiration and bone grafting are routine clinical techniques, while bone marrow concentration can be accomplished using specialized devices. Based on reasonable indication selection and strict operating procedures, bone marrow-enriched biomaterials can be rapidly prepared and implanted intraoperatively. This technology has already established a foundation for application both domestically and internationally and has effectively addressed the key clinical issue of inadequate activity in conventional bone graft materials, demonstrating significant application prospects.
