Research Progress on the Prevention and Treatment of Intestinal Ischemia-reperfusion Injury with Traditional Chinese Medicine
- VernacularTitle:中药防治肠缺血再灌注损伤研究进展
- Author:
Ke WU
1
;
Zhengyu ZHANG
;
Qiulin WANG
;
Mengnan LIU
;
Wei REN
;
Wubin GUO
Author Information
- Publication Type:Journal Article
- Keywords: Active components of traditional Chinese medicine; Chinese patent medicines; Intestinal ischemia-reperfusion injury; Mechanisms
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(7):1801-1814
- CountryChina
- Language:Chinese
- Abstract: Ischemic bowel disease(IBD)is a prevalent intestinal vascular disease that poses a serious threat to patients' lives and health.Tthe key pathological process of ischemic bowel disease is intestinal ischemia-reperfusion(II/R)injury.If not diagnosed and treated in a timely manner,it can lead to life-threatening conditions such as peritonitis,intestinal gangrene perforation,and multiple organ dysfunction.Current treatments primarily focus on symptomatic and surgical interventions,lacking targeted pharmacological therapies.A substantial body of research has found that traditional Chinese medicine(TCM)exhibits a protective effect against II/R injury.This review systematically elaborated on the mechanisms by which various TCM bioactive components,including Astragaloside IV,Ginsenosides,Salvianolic acids,and Tetramethylpyrazine,as well as compound formulations such as Shenqi injection,Taoren Chengqi decoction,and Sini decoction ameliorate II/R injury.These findings provide novel research perspectives for developing TCM-based therapeutics for IBD.
