Reduced clonidine rapid eye movement sleep suppression in patients with major depression

VernacularTitle:抑郁症患者可乐定快速眼运动睡眠抑制试验的对照研究
Author: Jize HU ¹ ; Jing CHEN ¹ ; Chiyi HU ¹
Author Information

1. 深圳市精神卫生研究所
Publication Type:Journal Article
From: Chinese Journal of Psychiatry 2001;34(1):31-33
CountryChina
Language:Chinese
Abstract: Objective　To study the functional condition of α2-adrenergic receptors in patients with major depression. Methods　Sleep EEG of 15 depressed patients diagnosed according to CCMD-2-R was compared with that of 15 normal controls. Clonidine hydrochloride was administered intravenously within 10 minute after the first rapid eyemovement (REM) sleep period. Results　The percent of REM in depressive patients was higher than in controls at baseline. There was no significant differences between the two groups in NREM after clonidine administration, but the percent of REM, frequency of REM and time of REM decreased in the two groups. The interval between the first and the second REM period (REM1-REM2) decreased more in patients with depression than in controls(P<0.01). It was suggested clonidine had little influence on the NREM sleep, but significantly effected on the REM lantency, total REM period, and interval between REM1 and REM2, and REM sleep response to clonidine bluntly in depression. Conclusion　It indicates there may be deficiency of α2-adrenergic receptors in major depression.