Efficacy of low-temperature plasma surgery for the treatment of OSAHS in children and its effects on inflammatory response,immune function,pain and sleep quality
10.3969/j.issn.1005-202X.2025.07.017
- VernacularTitle:低温等离子手术治疗儿童OSAHS的疗效及其对炎症反应、免疫功能、疼痛和睡眠情况等的影响
- Author:
Ling QIAO
1
;
Shihua TANG
1
;
Jiahao YAO
1
Author Information
1. 安徽省淮南新华医疗集团新华医院耳鼻喉科,安徽 淮南 232000
- Publication Type:Journal Article
- Keywords:
obstructive sleep apnea-hypopnea syndrome;
children;
low-temperature plasma surgery;
inflammatory response;
immune function;
pain;
sleep
- From:
Chinese Journal of Medical Physics
2025;42(7):956-961
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the therapeutic efficacy of low-temperature plasma surgery for children with obstructive sleep apnea-hypopnea syndrome(OSAHS)and its effects on inflammatory response,immune function,pain,and sleep quality for providing a basis for the rational treatment of OSAHS.Methods A prospective study was conducted on 92 children with OSAHS from January 2021 to December 2023,and they were randomly divided into control group(n=46)and pilot group(n=46).Control group were given conventional tonsil and adenoidectomy,while observation group were given low-temperature plasma tonsil and adenoid ablation.These patients in both groups were followed-up for 6 months after surgery,and there was no lost case during the follow-up period.The two groups were compared for the efficacy at 6 months after surgery,surgery-related indexes,scores of visual analogue scale for pain at 1,2,and 3 days after surgery,sleep quality before and at 6 months after surgery,inflammatory response,immune function,and the occurrence of complications during the 6 month follow-up period.Results Compared with control group,pilot group had higher overall effective rate at 6 months postoperatively(93.48%vs 78.26%,P<0.05),less intraoperative bleeding,and shorter operation and hospitalization time(P<0.05).The visual analog scale score gradually decreased in both groups at 1,2,3 days postoperatively,and the scores were lower in pilot group than in control group(P<0.05).Compared with those before surgery,apnea hypoventilation index and respiratory disturbance index were lower in both groups at 6 months postoperatively,with lower indicator values in the pilot group(P<0.05);while the lowest blood oxygen saturation increased in the two groups,with higher indicator values in the pilot group(P<0.05).Compared with those before surgery,serum procalcitonin,interleukin-1β,interleukin-6,high sensitive C-reactive protein,tumor necrosis factor-α,and whole-blood CD8+were lower in both groups at 3 days postoperatively,with lower indicator values in pilot group(P<0.05);while whole-blood CD3+,CD4+,CD4+/CD8+were higher in both groups at 3 days postoperatively,with higher indicator values in pilot group(P<0.05).The total complication rate within 6 months of follow-up was lower in pilot group than in control group(4.35%vs 17.39%,P<0.05).Conclusion Low-temperature plasma surgery is effective and safe in children with OSAHS,and it is considered that it might be related to its contributions to improvements in surgery-related indexes,inflammatory response,immune function,pain and sleep quality.
