Correlation of neutrophil/lymphocyte ratio,monocyte/high density lipoprotein cholesterol ratio and mild cognitive impairment in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.09.001
- VernacularTitle:2型糖尿病患者轻度认知障碍与中性粒细胞/淋巴细胞比值、单核细胞/高密度脂蛋白胆固醇比值相关性的研究
- Author:
Jingjing CHEN
1
;
Yao FANG
;
Ruirui FU
;
Xiaoyan ZHOU
;
Changjiang YING
Author Information
1. 221000 徐州医科大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Mild cognitive impairment;
Neutrophil/lymphocyte ratio;
Monocyte/high density lipoprotein cholesterol ratio
- From:
Chinese Journal of Diabetes
2025;33(9):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of neutrophil/lymphocyte ratio(NLR),monocyte/high density lipoprotein cholesterol ratio(MHR)and mild cognitive impairment(MCI)in patients with type 2 diabetes mellitus(T2DM).Methods 159 T2DM patients hospitalized in the Department of Endocrinology,Affiliated Hospital of Xuzhou Medical University from February 2023 to April 2023 were selected.The subjects were divided into normal cognitive function(Con,n=72)group and MCI group(n=87)based on score of Montreal cognitive assessment scale(MoCA).NLR and MHR were calculated and compared between the two groups.Spearman correlation analysis was used to analyze the correlation between NLR,MHR and MoCA score.Logistic regression analysis of the factors influencing the association between T2DM with MCI.Receiver operator characteristic(ROC)curve was used to evaluate the predictive value of NLR and MHR for DM complicated with MCI.Results Compared with Con group,MCI group showed a significant increase in hemoglobin A1c(HbA1c),fasting plasma glucose,NLR,MHR,neutrophil count,monocyte count,serum creatinine,cystatin C,while high density lipoprotein cholesterol lymphocytes,visual space and executive function,naming,attention,language ability,abstract thinking,delayed memory,orientation and MoCA score decreased(P＜0.05).Spearman correlation analysis showed that there was a negative correlation between MHR,NLR and MoCA score,visuospatial and executive function,delayed recall and attention.Logistic regression analysis showed that NLR,MHR,HbA1c were all risk factors for MCI in T2DM.ROC curve analysis showed that the area under the curve of NLR combined with MHR for diagnosing T2DM with MCI was 0.872,with corresponding sensitivity of 81.6%and specificity of 87.5%.Conclusions NLR and MHR are closely related to MCI in T2DM patients.The combination of NLR and MHR have certain efficacy in prediction T2DM with MCI.
