Interaction between vitamin D deficiency and hemoglobin A1c level and type 2 diabetes mellitus with osteoporosis
10.3969/j.issn.1006-6187.2025.07.005
- VernacularTitle:维生素D与糖化血红蛋白的交互作用对2型糖尿病合并骨质疏松症影响的研究
- Author:
Rong PAN
1
;
Xiaoyan YANG
1
;
Wei WANG
1
Author Information
1. 030009 太原市中心医院内分泌科
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Hemoglobin A1c;
Diabetes mellitus,type 2;
Osteoporosis
- From:
Chinese Journal of Diabetes
2025;33(7):501-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the interaction between vitamin D(VD)and hemoglobin A1c(HbA1c)and its relationship with type 2 diabetes mellitus(T2DM)combined with osteoporosis(OP).Methods A total of 228 T2DM patients admitted to our hospital from February 2020 to April 2023 were selected and divided into OP group(n=65),osteopenia group(n=89)and T2DM group(n=74)according to the standard deviation of bone mineral density(BMD)decline.Logistic regression was used to analyze the relationship of 25-hydroxyvitamin D[25(OH)D]and HbA1c with OP.Restricted cubic spline model was used to analyze the dose-response relationship of 25(OH)D and HbA1c with OP in different genders.Results DM duration,fasting plasma glucose(FPG),C-telopeptide of type Ⅰ collagen,fasting insulin(FIns)and 2 hIns in the T2DM,osteopenia and OP groups were increased(P<0.05),while osteocalcin,25(OH)D,lumbar L1～L4,BMD of femoral neck and its proximal end,and total hip were decreased(P<0.05).The age and HbA1c in OP group were higher than those in T2DM and osteopenia groups(P<0.05),and the proportion of taking calcium preparations was lower than that in T2DM group(P<0.05).Logistic regression analysis showed that after adjusting for confounding factors,serum 25(OH)D(OR 0.145,95%CI 0.036～0.204)and HbA1c(OR 1.108,95%CI 1.013～1.140)were influencing factors of OP in T2DM patients.There was no nonlinear dose-response relationship between 25(OH)D,HbA1c and OP both in male and female T2DM patients.There were multiplication and additive interactions between serum 25(OH)D and HbA1c(P<0.05).Conclusions There is a multiplicative and additive interaction between serum 25(OH)D and HbA1c,both of which are risk factors for concurrent OP in T2DM patients.
