Effects of glycerol ingestion on pure tone audiometry,distortion products otoacoustic emission,and electrocochleography in patients with Ménière disease
10.3969/j.issn.1006-7299.2025.04.015
- VernacularTitle:口服甘油对梅尼埃病患者纯音听阈、畸变产物耳声发射及耳蜗电图测试的影响
- Author:
Hui PAN
1
;
Linlin WANG
1
;
Cheng LUO
1
;
Meng GONG
1
;
Mengjun WU
1
;
Yi SHU
1
;
Wen XIE
1
;
Hongjun XIAO
1
;
Bo LIU
1
Author Information
1. 华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科,耳鼻咽喉科研究所,湖北省耳聋及眩晕临床医学研究中心(武汉 430022)
- Publication Type:Journal Article
- Keywords:
Ménière disease;
Glycerol test;
Pure tone audiometry;
Distortion products otoacoustic emission;
Electrocochleography
- From:
Journal of Audiology and Speech Pathology
2025;33(4):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glycerol ingestion on pure tone audiometry(PTA),distor-tion products otoacoustic emission(DPOAE),and electrocochleography(ECochG)in patients with Ménière disease(MD).Methods Glycerol test was conducted in 50 patients with MD.PTA was performed in four series:before glycerol intake,1,2 and 3 hours after intake.DPOAE and ECochG were performed before glycerol intake and 2 hours after intake.All results were analyzed to assess the effect of glycerol on cochlear function of patients with MD.Results ① 55％of MD patients tested positive in PTA glycerol test,and the positive rate increased gradually after 1-3 hours of glycerin ingestion(P＜0.05).For the 33 positive ears,the pure tone threshold decreased the most between 1-2 hours and reached the lowest thresholds at 3 hours.Thresholds at 0.5 kHz,1 kHz,2 kHz dropped the most.② The positive rate of DPOAE glycerol test was 56.67％,with 34 positive ears showing a sig-nificant increase in amplitude between 0.75-2 kHz of f2.③ The positive rate of ECochG glycerin test was 13.64％.The decrease of-SP/AP ratio was not statistically significant before and after ingestion of glycerin(P＞0.05).Conclusion Ingestion of glycerin could alter to varying degrees of the results of PTA,DPOAE and ECo-chG,and influence the cochlear function to some extent.
