Advances in the treatment of spinal cord injury by induced pluripotent stem cells transplantation
10.3760/cma.j.cn121113-20250703-00614
- VernacularTitle:诱导多能干细胞移植修复脊髓损伤的研究进展
- Author:
Anqiao XU
1
;
Moran SUO
1
;
Zhonghai LI
1
Author Information
1. 大连医科大学附属第一医院骨科，大连 116011
- Publication Type:Journal Article
- Keywords:
Induced pluripotent stem cells;
Spinal cord injuries;
Cell transplantation;
Spinal cord regeneration
- From:
Chinese Journal of Orthopaedics
2025;45(19):1275-1282
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury (SCI), as a serious traumatic disease of the central nervous system, often leads to irreversible damage to neurological function and has a high disability rate. Induced pluripotent stem cells (iPSCs) have the ability of self-renewal capacity and multilineage differentiation potential, and thus show broad application prospects and research value in the repair of SCI. iPSCs can replace damaged cells by directionally differentiating into neurons, oligodendrocytes, etc., secrete neurotrophic factors to optimize the microenvironment, promote myelin regeneration, and regulate immune responses. In recent years, research has concentrated on refining the directional differentiation protocol of iPSCs, improving survival rate and functional integration of transplanted cells, and actively exploring combined treatment strategies with biomaterial scaffolds, electrical stimulation, etc., to enhance the repair effect. Preclinical studies substantiate that iPSC transplantation can improve motor function, and early-phase clinical trials have also demonstrated its biological safety. Furthermore, iPSCs avoid ethical controversies and can be applied to disease modeling and mechanism research.
