Analysis of clinical features and prognostic factors of primary testicular lymphoma
10.3969/j.issn.1009-8291.2025.09.009
- VernacularTitle:原发性睾丸淋巴瘤单中心临床特征和预后因素分析
- Author:
Jixin CHEN
1
;
Ruochen QI
;
Guohui WANG
;
Xiaoyan ZHANG
;
Tong XU
;
Yan LI
;
Xiang REN
;
Shichao HAN
;
Weijing JIA
;
Shuaijun MA
Author Information
1. 武警青海总队医院泌尿外科,青海西宁 810000
- Publication Type:Journal Article
- Keywords:
primary testicular lymphoma;
orchiectomy;
CHOP chemotherapy;
central nervous system;
diffuse large B-cell lymphoma;
NK/T-cell lymphoma
- From:
Journal of Modern Urology
2025;30(9):779-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features,treatment and prognosis of primary testicular lymphoma(PTL),so as to provide reference for the standardized diagnosis and treatment of this disease.Methods Clinical data of 13 PTL cases treated in Xijing Hospital during Jan.2014 and Dec.2024 were retrospectively collected.The patients' diagnosis,treatment methods and prognosis were summarized.Results All 13 patients underwent orchiectomy of the affected side.According to the postoperative pathological results,11 cases were diagnosed as diffuse large B-cell lymphoma and 2 as NK/T-cell lymphoma.Among the 11 cases with diffuse large B-cell lymphoma,10 received immunotherapy and chemotherapy according to the international standardized treatment plan,and 5 received preventive myeloablative injection therapy.Recurrence in the contralateral testis occurred in 3 cases,1 complicated with central nervous system infiltration died,and another 1 refusing chemotherapy had contralateral testicular metastasis.Of the 2 cases with NK/T-cell lymphoma,1 received systemic chemotherapy and died after central nervous system recurrence,and another 1 died 1 month after surgery whithout undergoing chemotherapy.Conclusion Primary testicular lymphoma is highly invasive with poor prognosis.Patients with NK/T-cell lymphoma have extremely poor prognosis,while those with diffuse large B-cell lymphoma have relatively better prognosis.However,even after comprehensive treatment,it is still prone to recurrence in the testis and the central nervous system.
