Research advances on oncolytic viruses and their vectors for bladder cancer treatment
10.3969/j.issn.1009-8291.2025.09.001
- VernacularTitle:溶瘤病毒及其载体用于膀胱癌治疗的研究进展
- Author:
Zhenxing ZHAI
1
;
Zhiping WANG
1
Author Information
1. 兰州大学第二医院泌尿外科,甘肃省泌尿系统疾病临床医学研究中心,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
bladder cancer;
oncolytic virus;
viral vector;
adenovirus vector;
lentiviral vector;
adeno-associated virus vector;
immunotherapy;
chemotherapy;
radiotherapy
- From:
Journal of Modern Urology
2025;30(9):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer has the characteristics of multiple and easy recurrence after surgery.At present,the main treatment methods include surgery,chemotherapy,radiotherapy,and so on.However,the recurrence rate and metastasis rate are still very high,seriously threatening human health.Oncolytic viruses have become an important part of a comprehensive cancer treatment strategy.Compared with surgery,radiotherapy and chemotherapy,oncolytic virus therapy is more precise and less toxic,which is expected to significantly improve patients' quality of life.However,the therapeutic effects of oncolytic viruses alone are satisfactory.Currently,oncolytic viruses are combined with immunotherapy,chemotherapy or radiotherapy to improve the overall anti-tumor effects.The combination of oncolytic viruses and immunotherapy has a relatively broader prospect.This article reviews the research progress of the clinical application of adenovirus vectors,lentiviral vectors,adeno-associated virus vectors,and oncolytic viruses combined with immunotherapy,chemotherapy,and radiotherapy for bladder cancer.
