Study on the Relationship between Serum PGRN,PTX3,KL-6 and the Prognosis of Patients with AECOPD Combined with Type Ⅱ Respiratory Failure after Nasal High-Flow Humidified Oxygen Therapy
10.13241/j.cnki.pmb.2025.18.017
- VernacularTitle:血清PGRN、PTX3、KL-6与经鼻高流量湿化氧疗治疗的AECOPD合并Ⅱ型呼吸衰竭患者预后关系研究
- Author:
Ben LIU
1
;
Xian-hong LIU
1
;
Nan ZHANG
1
Author Information
1. 自贡市第一人民医院呼吸与危重症医学科 四川自贡 643000
- Publication Type:Journal Article
- Keywords:
Nasal high-flow humidified oxygen therapy;
Acute exacerbation of chronic obstructive pulmonary disease;
Type Ⅱ respiratory failure;
Progranulin;
Pentraxin 3;
Krebs von den lungen-6;
Prognosis
- From:
Progress in Modern Biomedicine
2025;25(18):3003-3009,2948
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum progranulin(PGRN),pentraxin 3(PTX3),krebs von den lungen-6(KL-6)and the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)combined with type Ⅱ respiratory failure(RF)after nasal high-flow humidified oxygen therapy.Methods:160 patients with AECOPD combined with type Ⅱ RF who were treated in Zigong First People's Hospital from June 2022 to June 2024 were retrospectively selected,all patients received nasal high-flow humidified oxygen therapy,and they were divided into death group(38 cases)and survival group(122 cases)according to the prognosis of patients after treatment.The differences of serum PGRN,PTX3 and KL-6 levels and clinical data between two groups before treatment were compared.Logistic regression was applied to analyze the influencing factors of the poor prognosis of patients,and the receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of related risk factors for the poor prognosis of patients.Results:According to the prognosis evaluation,122 cases(76.25％)were in survival group,and 38 cases(23.75％)were in death group.Compared with survival group,serum PGRN,PTX3,KL-6,C-reactive protein(CRP),arterial partial pressure of carbon dioxide(PaCO2)and the number of AECOPD episodes in the past 1 year before treatment in death group were significantly increased,while the arterial partial pressure of oxygen(PaO2)was significantly decreased,the differences were statistically significant(P＜0.05).Logistic multivariate regression analysis showed that,elevated PGRN(OR=1.138),elevated PTX3(OR=1.182)and elevated KL-6(OR=1.162)were risk factors for death in patients with AECOPD combined with type Ⅱ RF after nasal high-flow humidified oxygen therapy(P＜0.05),and elevated PaO2(OR=0.758)was protective factor(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum PGRN,PTX3 and KL-6 in predicting the death of patients with AECOPD combined with type Ⅱ RF after nasal high-flow humidified oxygen therapy was 0.816,0.731 and 0.695 respectively,the AUC of the combined prediction of the three was 0.893,which was significantly higher than that of the single prediction.Conclusion:The levels of serum PGRN,PTX3 and KL-6 in patients with AECOPD combined with type Ⅱ RF are increased,which have high predictive value for the poor prognosis of patients with AECOPD combined with type Ⅱ RF after nasal high-flow humidified oxygen therapy.
