Research Progress on the Correlation between Pathogenesis of Idiopathic Pulmonary Fibrosis Combined with Lung Cancer
10.13241/j.cnki.pmb.2025.18.020
- VernacularTitle:特发性肺纤维化合并肺癌发病机制的相关性研究进展
- Author:
Jie-xuan WANG
1
;
Ren-wei XU
1
;
Jian-an CHEN
1
;
Jia-xin ZHANG
1
;
Wen-wen QU
1
Author Information
1. 广州医科大学附属第五医院呼吸与危重症医学科 广东 广州 510700
- Publication Type:Journal Article
- Keywords:
Idiopathic pulmonary fibrosis;
Lung cancer;
Epidemiology;
Pathogenesis;
Clinical features
- From:
Progress in Modern Biomedicine
2025;25(18):3023-3031
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)and lung cancer(LC)pose a serious threat to human health,the prognosis of IPF is poor,the 5-year survival rate is low,and the incidence rate and mortality of LC are high.At present,IPF combined with LC(IPF-LC)has attracted much attention,but the pathogenesis is unclear.Epidemiology shows that,the risk of LC in IPF patients is 7 times than that of the general population,the incidence rate varies in different regions,which is related to smoking rate and diagnostic criteria.In terms of pathogenesis,chronic inflammation,angiogenesis,signaling pathways,aging,gene mutations,epithelial mesenchymal transition(EMT),and immune dysfunction are common pathogenic factors of both,and pathological changes such as smoking and pulmonary fibrosis increase the risk of LC.Thoroughly studying these mechanisms is of great significance for the early diagnosis,treatment strategy formulation,and improvement of patient prognosis of IPF-LC.
