Relationship between systemic immune inflammation index and vitamin D in patients with type 2 diabetes based on restricted cubic spline
10.3969/j.issn.1006-5725.2025.15.015
- VernacularTitle:基于限制性立方样条分析2型糖尿病患者系统免疫炎症指数与维生素D的关系
- Author:
Min ZHAO
1
;
Zhiwen LI
1
;
Chenglong HUANG
1
;
Xiaoju SHEN
1
;
Guangming HUANG
1
Author Information
1. 广西医科大学第一附属医院药学部(广西 南宁 530021)
- Publication Type:Journal Article
- Keywords:
vitamin D;
type 2 diabetes;
systemic immune inflammation index;
restricted cubic spline
- From:
The Journal of Practical Medicine
2025;41(15):2393-2397
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma vitamin D levels and a novel inflam-matory marker,the systemic immune-inflammatory index(SII),in patients with type 2 diabetes.Methods This study adopted a cross-sectional design,in which patients diagnosed with type 2 diabetes who were admitted to the First Affiliated Hospital of Guangxi Medical University were enrolled as study participants.Data on demographic characteristics,medical history,physical examination findings,and laboratory test results were systematically collected.Participants were categorized into three groups based on their serum vitamin D levels:deficient,insuffi-cient,and sufficient.The relationship between vitamin D levels and the SII was evaluated using a multivariate linear regression model.Additionally,a restricted cubic spline model was employed to assess the nonlinear dose-response association between vitamin D levels and SII.Results This study enrolled a total of 5,716 patients with type 2 diabetes.A statistically significant difference in the SII was observed across groups with varying vitamin D levels(P<0.05),with the highest SII value found in the vitamin D-deficient group.Multivariate linear regression analysis revealed that,after adjusting for potential confounding factors including gender,age,season of blood collection,body mass index,hypertension,dyslipidemia,and chronic kidney disease,vitamin D levels were negatively associ-ated with SII(β=-2.68,95%CI:-3.56 to-1.81,P<0.001).Compared with the vitamin D-deficient group,the vitamin D-sufficient group exhibited significantly lower SII levels(β=-78.42,95%CI:-137.90 to-18.93,P=0.01).Furthermore,the restricted cubic spline model indicated a nonlinear dose-response relationship between vita-min D levels and SII(P<0.001).Conclusion There is a significant inverse correlation between plasma vitamin D levels and the SII in patients with type 2 diabetes.
