Research Progress on Ferroptosis in Epilepsy
10.13241/j.cnki.pmb.2025.18.021
- VernacularTitle:铁死亡在癫痫中的研究进展
- Author:
Jing-jing GUO
1
;
Zhen-lin YANG
1
;
Xu ZHANG
1
;
Jin-zi LI
1
Author Information
1. 延边大学附属医院儿科 吉林延吉 133000
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Ferroptosis;
Regulatory Mechanisms;
Research Progress;
Treatment
- From:
Progress in Modern Biomedicine
2025;25(18):3032-3040
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy,as the second most common neurological disease,has diverse causes,complex,difficult to treat,and disabling characteristics,which impose a heavy burden on patients' families and social life.Long term recurrent epileptic seizures and poor control lead to neuronal inactivation and cognitive impairment in patients.Therefore,it is becoming increasingly important to find new targeted treatment methods and explore the molecular regulatory mechanisms of epilepsy on neuronal damage.Iron induced cell death is a novel programmed cell death mediated by ferrous ions,characterized by the accumulation of ferrous ions,harmful lipid peroxides,and lethal reactive oxygen species,leading to damage to mitochondrial function and structure.With recent in-depth research on ferroptosis,it has been found that inhibiting ferroptosis related targets and pathways can alleviate seizures and progression of epilepsy and protect neurons.This article provides a brief overview of the molecular mechanisms and related regulation of ferroptosis,its role in epilepsy,and recent advances in related treatments.
