Associations of Life's Crucial 9 and the risk of thyroid dysfunction: a cohort study
10.3760/cma.j.cn112338-20241217-00807
- VernacularTitle:生命九要素与甲状腺功能障碍风险关联的队列研究
- Author:
Juanjuan ZHANG
1
;
Yuerong HE
;
Zhiyuan TANG
;
Xiangdong SUN
;
Jiale SHEN
;
Jianping GONG
;
Chao LIU
;
Yang XIA
Author Information
1. 河北大学公共卫生学院，保定 071000
- Publication Type:Journal Article
- Keywords:
Thyroid dysfunction;
Hyperthyroidism;
Hypothyroidism;
Life's Crucial 9;
Cohort study
- From:
Chinese Journal of Epidemiology
2025;46(8):1400-1408
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the association between Life's Crucial 9 (LC9) and the risk of thyroid dysfunction (TD), as well as its potential predictive capacity.Methods:A total of 247 600 TD-free participants from the UK Biobank were enrolled in the study. The LC9 score was divided into three CVH groups: low (0-), medium (50-), and high (80-100). Cox proportional hazards regression models were used to calculate the HRs and 95% CIs of the risk of TD with LC9 CVH status. Calculate Harrell's concordance index ( C-index), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) to evaluate the predictive ability of the LC9 score and Life's Essential 8 (LE8) score. Results:During a median follow-up of 12.3 years, 5 515, 911, and 4 869 new cases of TD, hyperthyroidism, and hypothyroidism were documented, respectively. Participants with a high LE8 CVH group had 57.00% ( HR=0.43, 95% CI: 0.38-0.49), 55.00% ( HR=0.45, 95% CI: 0.34-0.60), and 58.00% ( HR=0.42, 95% CI: 0.37-0.47) lower risk of TD, hyperthyroidism, and hypothyroidism, respectively, than those with low CVH group. Compared with the LE8 score, the improvement in C-index for the LC9 score predicted TD risk was 0.004 (95% CI: 0.001-0.007), the NRI was 0.101 (95% CI: 0.021-0.103), and the IDI was 0.001 (95% CI: 0.000-0.001). Conclusions:The better CVH status, defined by LC9, was associated with a lower risk of TD. Compared to the LE8 score, the LC9 score demonstrated a significant enhancement in both risk discrimination and reclassification capability for TD risk.
