Evaluate Value of Chest Vascular CT Parameters Combined with PLR and IL-17 for the Prognosis of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension
10.13241/j.cnki.pmb.2025.18.008
- VernacularTitle:胸部血管CT参数联合PLR、IL-17对慢性阻塞性肺疾病急性加重期并发肺动脉高压患者预后的评估价值
- Author:
Yang LI
1
;
Ying ZHEN
1
;
Yang-guang CHENXI
1
Author Information
1. 南平市第二医院呼吸内科 福建南平 354200
- Publication Type:Journal Article
- Keywords:
Pulmonary hypertension;
Acute exacerbation of chronic obstructive pulmonary disease;
Chest vascular CT parameters;
Platelet-to-lymphocyte ratio;
Interleukin-17;
Prognosis;
Evaluate value
- From:
Progress in Modern Biomedicine
2025;25(18):2933-2940
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore evaluate value of chest vascular computerized tomography(CT)parameters combined with platelet-to-lymphocyte ratio(PLR)and Interleukin(IL)-17 for the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary hypertension.Methods:92 patients with AECOPD complicated with pulmonary hypertension admitted to our hospital from February 2023 to June 2024 were prospectively selected as the research objects,and they were divided into poor prognosis group(n=41)and good prognosis group(n=51)according to the different prognosis.The chest vascular CT parameters,PLR and IL-17 indicators of the two groups were compared.Multivariate Logistic regression analysis were used to analyze the influencing factors of prognosis in patients with AECOPD complicated with pulmonary hypertension.The receiver operating characteristic(ROC)curve was used to analyze the evaluate value of chest vascular CT parameters,PLR and IL-17 for the prognosis of patients with AECOPD complicated with pulmonary hypertension.Results:Among 92 patients with AECOPD complicated with pulmonary hypertension,41 patients were readmitted for treatment,and the incidence of poor prognosis was 44.57％.The age and disease duration of patients in poor prognosis group were higher than those in good prognosis group(P＜0.05).The ascending aortic diameter(AAD),main pulmonary artery diameter(MPAD),descending aortic diameter(DAD),PLR and IL-17 in poor prognosis group were higher than those in the good prognosis group(P＜0.05).Multivariate logistic analysis showed that elevated MPAD,AAD,DAD,IL-17,PLR,advanced age and long disease course were risk factors for poor prognosis in patients with AECOPD complicated with pulmonary hypertension.ROC curve analysis showed that the area under the curve(AUC)of the chest vascular CT parameters MPAD,AAD,DAD combined with PLR and IL-17 for evaluating the prognosis of AECOPD complicated with pulmonary hypertension was 0.923,which was significantly higher than that evaluated by each index alone.Conclusion:Elevated MPAD,AAD,DAD,IL-17,PLR,advanced age and long disease course are risk factors for poor prognosis in patients with AECOPD complicated with pulmonary hypertension,the combined detection of chest vascular CT parameters and PLR,IL-17 has a high evaluating value for the prognosis of patients with AECOPD complicated with pulmonary hypertension.
