Study on the effects of sitagliptin and metformin combined with zoledronic acid on glycolipid metabolism and bone metabolism levels in patients with diabetes mellitus complicated with osteoporosis
10.12173/j.issn.1005-0698.202505098
- VernacularTitle:西格列汀二甲双胍联合唑来膦酸对糖尿病合并骨质疏松患者糖脂代谢及骨代谢水平的影响研究
- Author:
Lu CHEN
1
;
Ye HUANG
;
Peilin GAO
;
Lingli HUANG
;
Rong DING
Author Information
1. 南通市康复医院(南通市第二人民医院)内分泌科(江苏南通 226002)
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Osteoporosis;
Sitagliptin and metformin;
Zoledronic acid;
Glucose and lipid metabolism;
Bone metabolism
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(9):1042-1048
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of sitagliptin and metformin combined with zoledronic acid in the treatment of type 2 diabetes mellitus(T2DM)complicated with osteoporosis(OP)on the levels of glucose and lipid metabolism and bone metabolism in patients.Methods Patients with T2DM combined with OP admitted to Nantong Second People's Hospital from January 2021 to January 2024 were selected as the research subjects and randomly divided into the combined group(sitagliptin and metformin combined with zoledronic acid)and the control group(zoledronic acid only).After 6 months of treatment,the clinical efficacy,glucose and lipid metabolism indicators[fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],bone metabolism indicators[osteoprotegerin(OPG),bone-specific alkaline phosphatase(BALP),osteocalcin(OC)]levels,changes in bone density,and incidence of adverse reactions were compared between the two groups before and after treatment.Results A total of 120 patients were included,with 60 patients in each group.After treatment,the total effective rate of the combination group was 93.33％,significantly higher than the control group's 73.33％(P＜0.05).The levels of FBG,2hPG,HbA1c,TC,TG,and LDL-C in two groups were significantly lower than those before treatment,while the levels of HDL-C,OPG,BALP,OC,and bone density in the femoral neck and lumbar spine were significantly higher than before treatment(P＜0.05);and all indicators of the combined group were better than those of the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Sitagliptin and metformin combined with zoledronic acid in the treatment of patients with T2DM complicated with OP is more effective in regulating their glycolipid metabolism and bone metabolism levels,increasing bone density,improving therapeutic effects,and it has better safety than zoledronic acid alone.
