Clinical study on the application of antimicrobial peptide spray in the prevention and treatment of che-moradiotherapy-associated oral mucositis in patients with hematologic malignancies
10.3969/j.issn.1001-3733.2025.05.009
- VernacularTitle:抗菌肽喷剂在防治血液系统恶性肿瘤放化疗相关口腔黏膜炎中的临床应用研究
- Author:
Xiaoling CHEN
1
;
Luming DENG
;
Kefeng WU
;
Xiaoli MA
;
Jinqi HUANG
Author Information
1. 524001 湛江,广东医科大学附属医院药学部
- Publication Type:Journal Article
- Keywords:
Oral mucositis;
Tumor;
Chemoradiotherapy;
Antimicrobial peptide spray;
VAS;
Antibiotics;
NNT
- From:
Journal of Practical Stomatology
2025;41(5):630-635
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the preventive effect of an antimicrobial peptide spray on chemoradiotherapy-induced oral mu-cositis in patients with hematologic malignancies.Methods:From December 2021 to July 2023,a total of 191 newly diagnosed pa-tients with hematologic malignancies undergoing concurrent chemoradiotherapy at our hospital were included in the study.Patients were divided into a treatment group(n=124,received antimicrobial peptide spray)and a control group(n=67,received placebo spray).All patients underwent standardized chemoradiotherapy regimens and oral care.Outcomes compared between groups includ-ed the incidence and severity of oral mucositis,ulcer healing time,pain scores,antibiotic usage,inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)],duration of neutropenia,adverse events,and quality of life.Results:The incidence of oral mucositis in the treatment group was significantly lower than in the control group(12.90％vs.31.34％,P＜0.05),with a relative risk reduction(RRR)of 58.84％,absolute risk reduction(ARR)of 18.44％,and a number needed to treat(NNT)of 5.423.The treatment group showed shorter ulcer healing time,lower pain scores,reduced antibiotic usage and intensity,lower mean levels of CRP and PCT,and a shorter duration of neutropenia.The incidence of exacerbated local pain and drug-related adverse reactions was also significantly lower in the treatment group,compared to the control group(P＜0.05),with no evident systemic toxicity ob-served.Patients in the treatment group reported higher quality of life and satisfaction scores(both P＜0.05).Conclusion:The an-timicrobial peptide spray effectively reduces the incidence and severity of chemoradiotherapy-associated oral mucositis,mitigates in-flammation and infection risk,and improves quality of life.
