Relationship between serum Cc16 and CD62E expression levels and the severity of neonatal respiratory distress syndrome and pulmonary ultrasound scores
- VernacularTitle:血清Cc16、CD62E表达水平与新生儿呼吸窘迫综合征严重程度和肺部超声评分的关系
- Author:
Wenjing JIANG
1
;
Jingxiao GUO
;
Aiqiao GENG
Author Information
- Publication Type:Journal Article
- Keywords: neonborn; respiratory distress syndrome; E-selectin; Clara cell protein 16; lung ultrasound score
- From: Tianjin Medical Journal 2025;53(8):836-840
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the relationship between serum levels of Clara cell protein 16(Cc16),E-selectin(CD62E),the severity of neonatal respiratory distress syndrome(NRDS)and lung ultrasound scores.Methods A total of 200 neonates with NRDS were selected in this study.The severity of the disease was assessed using oxygenation index(P/F).The neonates were divided into three groups:the mild group(46 cases),the moderate group(65 cases)and the severe group(89 cases).The serum levels of Cc16 and CD62E were compared between the three groups.In addition,based on the lung ultrasound scores,neonates were divided into the low-score group(score＜12 points,n=127),the medium-score group(score 12-24 points,n=51)and the high-score group(score>24 points,n=22).The receiver operating characteristic(ROC)curve was used to evaluate the predictive efficacy of the combined detection of serum Cc16,CD62E and lung ultrasound score for severe NRDS.Results Compared with the mild group,the serum levels of Cc16 and CD62E,and lung ultrasound scores were higher in the moderate group and the severe group(P＜0.05).Compared with the low lung ultrasound score group,the serum levels of Cc16 and CD62E were higher in the moderate lung ultrasound score group and the high lung ultrasound score groups(P＜0.05).Cc16 and CD62E were positively correlated with the severity of NRDS(rs=0.679 and 0.680,P＜0.01),and they were also positively correlated with lung ultrasound scores(r=0.692 and 0.685,P＜0.01).ROC analysis showed that the combined detection of Cc16,CD62E and lung ultrasound scores had a relatively high diagnostic value for severe NRDS(P＜0.05).Conclusion The serum levels of Cc16 and CD62E in NRDS neonates are positively correlated with disease severity and lung ultrasound scores.
