Dynamic mutual damage between breast cancer and mixed anxiety and depressive disorder:a traditional Chinese medicine analysis of"earth stagnation and wood depression"theory
10.3969/j.issn.1006-2157.2025.09.004
- VernacularTitle:从"土壅木郁"辨析乳腺癌和混合性焦虑与抑郁障碍的动态互损
- Author:
Yingyi WEI
1
;
Feifei LI
1
;
Yufei SHAN
1
;
Yongrui YAN
1
;
Youyang SHI
1
;
Sheng LIU
1
Author Information
1. 上海中医药大学附属龙华医院 上海 200032
- Publication Type:Journal Article
- Keywords:
earth stagnation and wood depression;
breast cancer;
mixed anxiety and depressive disorder
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(9):1203-1210
- CountryChina
- Language:Chinese
-
Abstract:
This artical starts from the perspective of"earth stagnation and wood depression"to analyze the dynamic mutual impairment process between breast cancer and mixed anxiety and depressive disorder(MADD),integrating pathological evidence of mutual causality between physical impairment and internal injury by emotional distress,to provide a theoretical framework elucidating the intrinsic unity of the microbiota-neuro-tumor interaction network in the comorbidity vicious cycle.The comorbidity of breast cancer and MADD manifests dynamic mutually aggravating impairment,with core pathogenesis according to the traditional Chinese medicine theory of"earth stagnation and wood depression":spleen earth stagnation leads to dampness-turbidity obstruction,while dysfunction of the middle jiao pivot result in abnormal liver qi conveyance and dispersion;liver depression transforming into fire further over-restricts on spleen earth.Mutual over-restriction and counter-restriction between the two causes toxic fire,phlegm and blood stasis to conglomerate into masses.The lingering disease progression causes mutual damage between body and spirit,leading to progressive consumption until physical collapse and spiritual decline,ultimately culminating in earth exhaustion and wood withering,toxins infiltrating the extraordinary vessels,and divorce of yin-yang.Gut microbiota dysbiosis induces abnormalities in the metabolic-immune-neuroendocrine network,driving emotional disorders and interacting with the tumor microenvironment to exacerbate deterioration.This mechanism not only validates the concept of"earth stagnation and wood depression-mutual physical-mental impairment",but also elucidates its role in inducing multi-system cascade failure,ultimately culminating in a pathological process marked by the emergence of severe clinical manifestations.
