Analysis on negative conversion of syphilis-specific antibody and related factors in children born to pregnant women with syphilis in China, 2021
10.3760/cma.j.cn112338-20241203-00767
- VernacularTitle:2021年中国梅毒感染孕产妇所生儿童的梅毒特异性抗体转阴及相关因素分析
- Author:
Hongqiao ZHENG
1
;
Ailing WANG
;
Xiaoyan WANG
;
Qian WANG
;
Shuiling QU
;
Dongxu HUANG
;
Yu WANG
;
Changhe WANG
Author Information
1. 中国疾病预防控制中心，北京 102206
- Publication Type:Journal Article
- Keywords:
Pregnant women;
Children;
Syphilis;
Syphilis-specific antibody;
Negative conversion
- From:
Chinese Journal of Epidemiology
2025;46(5):784-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the negative conversion of syphilis-specific antibody in follow-up in 0-18 months-old children born to pregnant women with syphilis in China in 2021 and analyze the related factors.Methods:The basic information of pregnant women with syphilis and follow-up information of their children in 2021 were extracted from the National Management Information System for the Prevention of mother-to-child transmission of HIV, syphilis and Hepatitis B. The logistic regression model was used to analyze related factors of negative conversion of syphilis-specific antibody.Results:In 2021, a total of 34 201 children was delivered by syphilis-infected pregnant women, and 23 592 (68.98%) children were included in this study. Negative conversion of syphilis-specific antibody occurred in 21 076 (89.34%) children, but not in 2 516 (10.66%) children. Multivariate logistic regression analysis identified several factors associated with a higher probability of the negative conversion of syphilis-specific antibody: prophylactic benzathine penicillin injection at birth (a OR=1.35,95% CI:1.10-1.65), mother's age 26-30 years (a OR=1.22,95% CI:1.01-1.46), 36-40 years (a OR=1.34, 95% CI:1.09-1.64), other ethnic groups (a OR=1.19,95% CI:1.04-1.36), non-syphilis-specific antibody titers less than 1∶8 during pregnancy (a OR=1.56,95% CI:1.37-1.78), penicillin treatment (a OR=1.56,95% CI:1.23-1.98) and standardized treatment (a OR=1.21,95% CI:1.11-1.32). Conclusions:In 2021,the level of syphilitic-specific antibody negative conversion in follow-up in children born to pregnant women with syphilis was high in China. According to the factors associated with syphilis-specific antibody negative conversion, it is necessary to develop the follow-up strategies for the children born to pregnant women.
