Effect of concentrated compound Danshen Jianli granules on the endocrinic function of rats following simulated high-intensity training
10.3760/cma.j.issn.1009-6906.2012.03.008
- VernacularTitle:复方丹参健力浓缩颗粒对模拟高强度训练大鼠内分泌功能的影响
- Author:
Yin-xiang CHEN
1
;
Jian-fa CHEN
;
Ping LI
;
Ming FU
;
Kui-long XIE
;
Ying-nian LV
Author Information
1. 解放军第四二二医院普外科,广东省湛江,524009
- Publication Type:Journal Article
- Keywords:
Compound danshen;
High-intensity exercise;
Endocrinic function;
Testosterone;
Corticosterone;
INF-γ;
IL-4
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2012;19(3):155-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of concentrated compound Danshen Jianli granules on the endocrinic function of rats following simulated high-intensity training at sea and the possible mechanism involved.Methods Forty male SD rats were randomly divided into 5 groups:the non-exercise control group,the high-intensity exercise control group,the high-intensity exercise with low dosage group (48 mg/kg),the high-intensity exercise with moderate dosage group (144 mg/kg) and the high-intensity exercise with high dosage group (686 mg/kg).Changes in the body weight and levels of endocrinic factors in the serum of rats in various groups were observed 4 weeks after gastric administration of the drug.Results When compared with the control group,the body weight of the rats in the high-intensity exercise control group decreased.The absolute values of WBC,lymphocytes,neutrophilic granulocytes decreased significantly.comparied with high-intensity exercise control group,The concentration of testosterone (T) in the serum decreased and that of corticosterone (C) increased(P ＜ 0.05 or P ＜ 0.01),while testosterone and corticosterone ratio (T/C ratio) decrease considerably ( P ＜ 0.05 or P ＜ 0.01 ).The concentration of INF-γ and IL-4 increased and their ratio decreased significantly ( P ＜ 0.05 or P ＜ 0.01 ).In the meantime,contents of INF-γ and IL-4 increased,while INF-γ/IL-4 ratio decreased significantly.Values of various blood cell counts in the moderate and high dosage groups elevated,corticosterone concentration decreased and the ratios of T/C and INF-γ/ IL-4 increased to normal level.Conclusions The moderate and high dosages of concentrated compound Danshen Jianli granules could obviously enhance endocrinic function and immunosuppression of the rats with simulated high-intensity training.
