Association between inflammation-related dietary patterns and cognitive impairment in older adults aged 65 years and above in longevity areas of China: a reduced rank regression analysis
10.3760/cma.j.cn112338-20241011-00627
- VernacularTitle:基于降秩回归分析的中国长寿地区65岁及以上老年人炎症相关膳食模式与认知功能损伤的关联分析
- Author:
Yang LI
1
;
Zihan LU
;
Yangyang XIONG
;
Wenjing CHEN
;
Jun WANG
;
Zenghang ZHANG
;
Chen CHEN
;
Wenhui SHI
;
Xi MENG
;
Zhenwei ZHANG
;
Zinan XU
;
Yuan XIA
;
Yiqi LI
;
Honglin LAI
;
Yujie LI
;
Cuipeng ZHANG
;
Yuming ZHAO
;
Yuebin LYU
;
Xiaoming SHI
Author Information
1. 南京医科大学公共卫生学院全球健康中心，南京 211166
- Publication Type:Journal Article
- Keywords:
Inflammation-related dietary pattern;
Cognitive impairment;
Older adults;
Reduced rank regression;
Inflammatory biomarkers
- From:
Chinese Journal of Epidemiology
2025;46(5):737-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between inflammation-related dietary patterns and the risk for cognitive impairment in older adults aged ≥65 years in longevity areas in China by using reduced rank regression (RRR) analysis.Methods:This study used cross-sectional data from the 2021 Healthy Aging and Biomarkers Cohort Study, including the information about study participants' demographic characteristics, lifestyles, daily life activities, and disease histories. Dietary intake was obtained by using a simplified food frequency questionnaire. Cognitive impairment was evaluated based on the Mini-Mental State Examination Scale combined with years of education. Fasting venous blood samples were collected to detect inflammatory markers, especially high-sensitivity C-reactive protein (hs-CRP) and the platelet-to-lymphocyte ratio (PLR). RRR analysis was used to obtain inflammation-related dietary patterns using hs-CRP and PLR as response variables. Multivariate logistic regression model was used to analyze the association between dietary pattern score and the risk for cognitive impairment. Restricted cubic spline was used to explore the dose response relationship, and mediation analysis was used to quantify the mediating effects of hs-CRP and PLR.Results:Two dietary patterns were identified with RRR. The primary pattern was characterized by higher intakes of flour, red meat, and dairy products, and lower intake of fresh vegetables, explaining 6.84% of the variance in food intake and 0.50% of the variance in inflammatory markers. Compared with the T1 group, the T3 group had significantly higher risk for cognitive impairment ( OR=1.242, 95% CI: 1.034-1.491). Each one standard deviation increase in the dietary pattern score was associated with an 8.7% increase in the risk for cognitive impairment ( OR=1.087, 95% CI: 1.008-1.172), with a significant linear trend (overall-model P<0.001, non-linear P=0.295). Mediation analysis indicated that hs-CRP mediated 6.2% of the association between the dietary pattern and the risk for cognitive impairment. Conclusion:The inflammation- related dietary pattern characterized by higher consumption of flour, red meat, and dairy products and lower consumption of fresh vegetables is associated with an increased risk for cognitive impairment in older adults, and hs-CRP partially mediates this association.
