Bullous haemorrhagic dermatosis induced by urokinase combined with low molecular weight heparin calcium
10.3760/cma.j.cn114015-20210425-00498
- VernacularTitle:尿激酶与低分子肝素钙联用致大疱性出血性皮肤病
- Author:
Huibo LIU
1
;
Liping PEI
;
Yuhong DING
;
Hongmei ZHANG
Author Information
1. 吉林大学第一医院二部皮肤科，长春 130031
- Publication Type:Journal Article
- Keywords:
Heparin, low-molecular-weight;
Skin diseases, vesiculobullous;
Urokinase
- From:
Adverse Drug Reactions Journal
2022;24(4):206-208
- CountryChina
- Language:Chinese
-
Abstract:
A 70-year-old female patient was treated with low molecular weight heparin calcium, levocarnitine, recombinant human erythropoietin, and ceftazidime due to end-stage renal disease, renal anemia, catheter-related infection, etc. At the same time, ceftazidime, urokinase, and low molecular weight heparin calcium was pumped into the long-term indwelling catheter to dredge the catheter because of suspected local bacterial capsule formation and long-term indwelling catheter blockage. On the 4th day of treatments, the patient developed mild pruritus. On the 5th day, it was found that the skin of her left upper limb and lower abdomen was scattered with dark red blood blisters ranging from 0.01 to 2 cm, with approximate hemispherical or irregular shape, clear boundary, and slight pain in touch. Nikolsky sign was negative. Bullous haemorrhagic dermatosis was diagnosed and it was considered to be caused by the combination use of urokinase and low molecular weight heparin calcium. The 2 drugs were stopped and heparin-free hemodialysis was given. The skin symptoms were relieved gradually. After 9 days of drug withdrawal, the blood blisters dried up and scabbed. At a 2-week follow-up, all blood scabs fell off by themselves.
