Development and application of the simulated system for spinal blast injury
10.3760/cma.j.issn.1009-6906.2011.03.015
- VernacularTitle:脊髓冲击伤模拟装置的研制与应用
- Author:
Hai-feng WANG
1
;
Jian FANG
1
;
Shao-bao PEI
1
;
Guang-xun ZHAO
1
;
Di ZHANG
1
Author Information
1. 解放军第一○五医院(安徽医科大学解放军临床学院)显微骨科,合肥,230031
- Publication Type:Journal Article
- Keywords:
Blast wave;
Spinal cord injury;
Simulated system;
Animal model
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2011;18(3):176-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a small blast-wave-generating system for the simulation of the effect of blast waves on injuries.Methods The system consisting of the gas storage chamber, the launching device, the blast wave analysis system and the animal fixer was developed with the principles of air dynamics, the technique of membrane rupture and sensor detection technology. Pressures of the gas source were set at 400, 500, 600, 700 and 800 kPa. Ultra pressure peak values, peak sustaining time and transmitting velocity of blast waves were recorded at the opening. 24 New Zealand white rabbits were randomly divided into 4 groups: group A (the control group), group B (with a gas pressure source of 400 kPa), group C (with a gas pressure source of 600 kPa), group D (with a gas pressure source of 800 kPa), each consisting of 6 animals. Laminectomy was performed at T9 and T10 to expose dura mater bursa. All the animals in the experimental groups with the exception of those in the control group sustained injuries with a single blast wave of different gas pressures. After 48 hours of injury, changes in the hind limb movement, sensory function and spinal cord pathology were evaluated with histological analysis.Results The waveform of the system was similar to the Friedlander waveform, a typical air-blast waveform. Positive pressure peak and propagation velocity increased with the increase of gas pressures, while the duration of pressure peak remained basically unchanged. For the animals in the B, C, and D groups, sensory and motor functions deteriorated obviously with the increase of gas pressures. Statistical significance could be seen in the scores of sensory and motor functions(P<0.01).Conclusions The developed system was capable of simulating blast waves, with the features of stable performance, safety and good reproducibility. It could ideally be used to simulate light, moderate and severe spinal cord blast injuries.
