Continuous endurance training alleviated whereas high-intensity interval training aggravated cardiac re-modeling in spontaneously hypertensive rats
10.3969/j.issn.1001-1242.2025.11.002
- VernacularTitle:持续耐力运动减轻而高强度间歇运动加重高血压大鼠心脏重塑的研究
- Author:
Changxi FU
1
;
Daning WANG
;
Yongsheng QIN
Author Information
1. 徐州工程学院体育学院,江苏省 徐州市,221008
- Publication Type:Journal Article
- Keywords:
high-intensity interval training;
continuous endurance training;
hypertension;
rats;
cardiac remodeling
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(11):1612-1620
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare effects of different training modalities on cardiac remodeling(including cardiac hyper-trophy,myocardial fibrosis,fetal gene expression and capillary angiogenesis)in spontaneously hypertensive rats(SHR)and to investigate potential mechanism.Method:Forty-five male SHR were randomly divided into sedentary(SHR-SED)group,continuous endurance training(SHR-CET)group and high-intensity interval training(SHR-HIIT)group,with ten normotensive Wistar-Kyoto rats serving as the normal control(NC)group.The exercise intensity(70%—90%maximal running speed),duration(1-4min)and exercise frequency(3-5d/w)were progressively increased g in SHR-HIIT group,while SHR-CET group consistently exercised at 60%of the maximal running speed.Both groups had equal en-ergy consumption over an intervention period of 12 weeks.After the intervention,caudal artery pressure was assessed by non-invasive blood pressure tester;cardiac structure and function was evaluated by echocardio-gram;histopathological detection was detected by HE and Masson staining;myocardial microvessel density(MVD)was measured by immunohistochemistry;protein expression of atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP),β-myosin heavy chain(β-MHC),hypoxia inducible factor-1α(HIF-1α),endothelial nitric oxide synthase(eNOS)and vascular endothelial growth factor(VEGF)was detected by Western Blot.Result:Compared with NC group,SHR-SED group had elevated blood pressure(P<0.05),concentric hyper-trophy in the left ventricle with decreased cardiac function and myocardial fibrosis,reduced MVD(P<0.05),and increased HIF-1α protein expression(P<0.05).Compared with SHR-SED group,SHR-CET group showed a decrease in blood pressure(P<0.05),left ventricular eccentric hypertrophy with enhanced cardiac function(P<0.05),reduced myocardial fibrosis,increased MVD(P<0.05),decreased HIF-1α expression(P<0.05),and in-creased eNOS expression(P<0.05).The SHR-HIIT group showed worsened left ventricular concentric hypertro-phy and increased BNP expression(P<0.05).Conclusion:Long-term continuous endurance training(CET)alleviated while high-intensity interval training(HI-IT)aggravated cardiac remodeling in hypertensive rats.Traditional CET remains the primary exercise rehabilita-tion method for hypertension,however,the safety and effectiveness of HIIT need to be further confirmed.
