Effect of HBO combined with naloxone hydrochloride in the treatment of coma following severe craniocerebral trauma
10.3760/cma.j.issn.1009-6906.2011.03.012
- VernacularTitle:高压氧联合盐酸纳洛酮对重型颅脑损伤后昏迷患者的疗效分析
- Author:
Xiao-wei JIANG
1
;
Zhong-yuan XUE
;
Zhi-cai LI
;
Ting-jiang CAI
;
Yang SONG
;
Dong WANG
;
Yi-tian CUI
;
Qing WAN
;
Lei YANG
;
Dong CHEN
Author Information
1. 解放军第九七医院神经外科,江苏省徐州,221004
- Publication Type:Journal Article
- Keywords:
Severe craniocerebral trauma;
Coma;
Hyperbaric oxygen;
Naloxone hydrochloride
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2011;18(3):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of HBO combined with naloxone hydrochloride in the treatment of coma following severe craniocerebral trauma.Methods Two hundred and ninety-nine patients with persisting coma following severe craniocerebral trauma were randomly divided into 3 groups: the hyperbaric oxygen group, the naloxone hydrochloride group and the HBO combined with naloxone hydrochloride group. On the basis of conventional therapy, patients were treated with HBO, or naloxone hydrochloride, or HBO combined with naloxone hydrochloride in the same course of treatment. Dynamic EEG, Glasgow coma scale (GCS) scores, Glasgow outcome scale (GOS) scores, long-term quality of Life Assessment Scale (KPS) scores were observed before and after treatment and statistical data were analyzed.Results After 3 months of treatment, GCS scores for the patients in the HBO combined with naloxone hydrochloride group were higher than those of the HBO group(P<0.05), and GOS scores for the patients in the HBO combined with naloxone hydrochloride group were significantly higher than those of the HBO group or the naloxone hydrochloride group. After 6 months of treatment, the EEG classification in patients of HBO combined with naloxone group was higher than that of the naloxone group, and KPS scores in patients of HBO combined with naloxone group were significantly better than those of the hyperbaric oxygen group and the naloxone hydrochloride group. After 6 months, the EEG classification, KPS scores for the patients in the HBO combined with naloxone hydrochloride group were significantly higher than those of the HBO group or the naloxone hydrochloride group(P<0.01).Conclusions HBO treatment combined with naloxone hydrochloride could produce better effect on patients with persistent coma following severe craniocerebral trauma, when comparisons were made with HBO and naloxone hydrochloride.
