Mediating effects of self-management and medication adherence between type D personality and viral load in HIV-infected individuals
10.3760/cma.j.cn115682-20240831-04861
- VernacularTitle:自我管理和服药依从性在HIV感染者D型人格与病毒载量间的中介效应
- Author:
Yanping JI
1
;
Qingbin DING
;
Tianyi BU
;
Kun WANG
;
Xue WANG
;
Jing ZHANG
Author Information
1. 哈尔滨医科大学附属第四医院感染三科，哈尔滨 150001
- Publication Type:Journal Article
- Keywords:
HIV infection;
Type D personality;
Viral load;
Self-management;
Medication adherence
- From:
Chinese Journal of Modern Nursing
2025;31(4):514-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mediating effects of self-management and medication adherence between type D personality and viral load in HIV-infected individuals.Methods:HIV patients who were newly diagnosed and undergoing antiretroviral therapy (ART) at the Heilongjiang AIDS Treatment Center of the Fourth Hospital of Harbin Medical University from October 2023 to March 2024 were enrolled by convenience sampling. Data were collected using the Type D Personality Scale-14 (DS-14), HIV Self-Management Scale (HIVSMS), and 8-item Morisky Medication Adherence Scale (MMAS-8). HIV-1 viral load was also measured. Pearson correlation analysis explored the relationships among type D personality, self-management, medication adherence, and viral load. The SPSS Process V4.0 macro was used to test the mediating effects.Results:A total of 318 questionnaires were distributed and 313 valid responses were collected (effective response rate: 98.43%). The mean scores for the 313 HIV-infected individuals were as follows: DS-14 (33.39±4.98), HIVSMS (29.84±4.41), and MMAS-8 (6.11±1.29). The mean viral load was (1 803.19±870.81) copies/ml. Pearson correlation analysis showed that type D personality was negatively correlated with self-management and medication adherence ( r=-0.307, -0.208, respectively; P<0.01) and positively correlated with viral load ( r=0.213; P<0.01). Medication adherence was negatively correlated with viral load ( r=-0.232; P<0.01), while self-management was positively correlated with medication adherence ( r=0.353; P<0.01). The mediation analysis revealed that self-management and medication adherence played a chain mediating role between type D personality and viral load, with a mediation effect value of 0.016, accounting for 8.08% of the total effect. Conclusions:Type D personality directly influences the viral load of HIV-infected individuals and indirectly affects it through the mediating effects of self-management and medication adherence.
