Supplementing aerobic exercise with transcranial magnetic stimulation better improves the cognitive functioning of early stage Parkinson′s disease patients
10.3760/cma.j.cn421666-20240907-00721
- VernacularTitle:重复经颅磁刺激联合有氧运动训练对早期帕金森病患者认知功能的影响
- Author:
Qi GU
1
;
Xue LI
1
;
Shaopu WU
1
;
Siyuan CHEN
1
;
Dongsheng LI
1
;
Jinhua ZHENG
1
;
Xiaoxue SHI
1
;
Jianjun MA
1
Author Information
1. 河南省人民医院神经内科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Parkinson′s disease;
Transcranial magnetic stimulation;
Exercise training;
Cognitive functioning
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(2):112-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any effect of combining transcranial magnetic stimulation (rTMS) with aerobic exercise on the cognitive functioning of early stage Parkinson′s disease (PD) patients.Methods:A total of 120 PD patients in the early stage were randomly divided into an observation group and a control group, each of 60. Both groups received conventional drug treatment and moderate-intensity aerobic exercise training, while the observation group was additionally provided with high-frequency rTMS treatment. Before and after 3 months of the treatments, everyone′s cognitive and motor functioning was evaluated using the Montreal Cognitive Assessment Scale (MoCA) and the third part of the Unified Parkinson′s Disease Rating Scale (UPDRS-Ⅲ), respectively. Negative emotions were evaluated using the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD). Auditory event-related potentials were also detected, and the latency and amplitude of P300 were analyzed.Results:The average MoCA, UPDRS-Ⅲ, HAMA and HAMD scores, as well as the amplitude and latency of P300 had improved significantly in both groups after the treatment. At that point the observation group′s performance was significantly better than that of the control group in terms of the MoCA′s visuospatial and executive function, attention and delayed recall indicators, and also total score. The observation group′s average HAMA score (10.55±3.11), HAMD score (9.78±4.10), the P300 amplitude [(11.29±2.21)μV] and latency [(384.75±48.26)ms] were also significantly better. The UPDRS-Ⅲ scores were negatively correlated with the visuospatial and executive function scores of the MoCA scale in the observation group before and after treatment, while the average HAMA score was negatively correlated with the attention and delayed recall scores.Conclusions:Supplementing aerobic exercise with rTMS can significantly improve the cognition and motor functioning of early stage PD patients. The combination is more effective than aerobic exercise alone. Such combined therapy is worthy of popularization and clinical application.
