Observation on the therapeutic effect of Sheng Mai San mixed Jiawei Sheng Xian Tang on heart failure with reduced ejection fraction of Qi deficiency blood stasis type
10.11958/20251179
- VernacularTitle:生脉散合加味升陷汤对气虚血瘀型射血分数降低的心力衰竭的疗效观察
- Author:
Yingjie LI
1
;
Hang ZHANG
;
Shaoting HAO
;
Fei XU
;
Weichao GUO
;
Hui SONG
;
Yanfen WANG
Author Information
1. 邯郸明仁医院心病二科(邮编 056000)
- Publication Type:Journal Article
- Keywords:
heart failure;
Sheng Mai San;
Sheng Xian Tang;
Qi deficiency blood stasis;
inflammation;
left ventricular ejection fraction
- From:
Tianjin Medical Journal
2025;53(8):860-864
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of Sheng Mai San mixed Jiawei Sheng Xian Tang on patients with heart failure with reduced ejection fraction(HFrEF)of Qi deficiency blood stasis type,and its impact on the immune inflammatory response of patients.Methods Ninety patients with HFrEF of Qi deficiency blood stasis type were selected and divided into two groups according to the treatment plan.Patients of the conventional group(42 cases)took sacubitril/valsartan sodium tablets orally.Patients of the combined group(48 cases)were treated with Sheng Mai San combined with Jiawei Sheng Xian Tang on the basis of the conventional group,one dose per day,and divided it in two servings used in the morning and evening.The symptoms of the patients were evaluated by using traditional Chinese medicine(TCM)syndrome score before and after the treatment respectively.Echocardiography technology was used to measure the left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF).Enzyme-linked immunosorbent assay was used to detect pentaggrin 3(PTX3),tumor necrosis factor-α(TNF-α),galectin-3(Gal-3),interleukin(IL)-8,IL-6,IL-33 and angiotensin Ⅱ(Ang Ⅱ).N-terminal pro-brain natriuretic peptide(NT-proBNP)was detected by immunofluorescence analysis.The therapeutic effect was evaluated based on the symptoms and the New York Heart Association(NYHA)cardiac function classification in the United States.Results After treatment,the levels of TCM syndrome scores,LVEDD,TNF-α,PTX3,IL-8,IL-6,IL-33,NT-proBNP,Gal-3 and AngⅡ decreased in both groups,and those in the combined group were lower than those in the conventional group(P＜0.05).The LVEF increased,and which were higher in the combined group than those of the conventional group(P＜0.05).After the treatment,the total effective rate of the combined group was higher than that of the conventional group(P＜0.05).Conclusion The Sheng Mai San mixed Jiawei Sheng Xian Tang as adjuvant therapy can effectively reduce the levels of immune inflammatory cytokines in HFrEF patients of Qi deficiency blood stasis type,improve their clinical symptoms and enhance therapeutic effect.
