Therole of macrophage-derived miRNA in immune regulation and clinical translation in idiopathic pulmonary fibrosis
10.3969/j.issn.1005-6483.20250809
- VernacularTitle:巨噬细胞微小RNA在特发性肺纤维化免疫调控与临床转化中的作用
- Author:
Litian MA
1
;
Hongtao DUAN
;
Zhaoyang WANG
;
Teng REN
;
Xiaolong YAN
Author Information
1. 710038 陕西西安,空军军医大学唐都医院胸腔外科
- Publication Type:Journal Article
- Keywords:
macrophages;
idiopathic pulmonary fibrosis;
microRNA;
exosomes;
immune regulation
- From:
Journal of Clinical Surgery
2025;33(9):948-952
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic Pulmonary Fibrosis(IPF)is a progressive disease characterized by declining respiratory function and high mortality.Macrophages play a pivotal role in its pathogenesis.Through polarization into pro-inflammatory M1 and pro-fibrotic M2 phenotypes,they contribute to a complex immunoregulatory network.In the early disease stages,M1 macrophage-mediated inflammation causes lung tissue injury,while M2 macrophages drive fibrogenesis by releasing pro-fibrotic factors such as TGF-β.Recent research has revealed that exosomes derived from macrophages serve as carriers for miRNAs,with specific miRNAs(e.g.,miR-328,miR-142-3p)demonstrating significant roles in pulmonary fibrosis.miR-328 promotes fibroblast proliferation and accelerates collagen deposition,whereas miR-142-3p attenuates fibrosis by modulating the TGF-β signaling pathway.Targeted intervention against these macrophage-associated miRNAs shows potential for clinical translation,potentially offering novel approaches for the early diagnosis and targeted therapy of IPF.However,translating these strategies into clinical practice requires overcoming challenges related to production and delivery systems.In conclusion,a deeper understanding of the mechanisms and translational applications of macrophage-derived miRNAs in IPF holds promise for ultimately improving patient prognosis and clinical outcomes.
