Effects of esketamine-mediated opioid-free anesthesia on postopera-tive gastrointestinal function in patients undergoing laparoscopic rad-ical resection of distal gastric cancer
10.12092/j.issn.1009-2501.2025.10.001
- VernacularTitle:艾司氯胺酮介导无阿片麻醉对腹腔镜远端胃胃癌根治术患者术后胃肠功能的影响
- Author:
Yidong XU
1
;
Siqi YANG
;
Tao WANG
;
Liuyan WU
;
Ting PAN
;
Sen WANG
;
Zhenhui ZHOU
;
Shasha YOU
;
Xingzi CHEN
;
Saifu WANG
;
Linjun WANG
;
Cunming LIU
;
Chun YANG
;
Di WANG
Author Information
1. 南京医科大学第一附属医院麻醉与围术期医学科,南京 210029,江苏;南京市栖霞区医院麻醉科,南京 210023,江苏
- Publication Type:Journal Article
- Keywords:
esketamine;
opioid-free anesthesia;
gastrointestinal function;
laparoscopic gastrectomy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(10):1297-1304
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the impact of es-ketamine-mediated opioid-free anesthesia(OFA)on postoperative gastrointestinal function in patients undergoing laparoscopic distal gastrectomy for gas-tric cancer.METHODS:A total of 150 pa-tients,scheduled for elective laparoscopic distal gas-trectomy for gastric cancer and meeting the inclu-sion and exclusion criteria,were randomly assigned to either the OFA group or the opioid-based anes-thesia(OBA)group using a random number ta-ble,with 75 patients in each group.The OFA group was administered an anesthesia regimen pri-marily consisting of esketamine,while the OBA group received conventional opioid anesthesia,pri-marily consisting of sufentanil and remifentanil.The primary outcome measure was postoperative flatus time,defined as the interval from the end of sur-gery to the first passage of gas.RESULTS:The OFA group exhibited a shorter postoperative flatus time compared to the OBA group(P＜0.01).Intraopera-tive blood loss and norepinephrine consumption were significantly less in the OFA group compared to the OBA group(P＜0.05);the postoperative HADS-D score was better in the OFA group than in the OBA group,and both the OFA and OBA groups showed significantly lower postoperative HADS-A and HADS-D scores compared to their preoperative levels(P＜0.05);the incidence rate of abdominal distension was significantly lower in the OFA group compared to the OBA group(P＜0.05).CONCLUSION:The use of esketamine-mediated opioid-free anesthesia can expedite gastrointestinal function recovery,reduce hospital stay duration,and decrease postoperative adverse reactions in patients undergoing laparo-scopic distal gastrectomy for gastric cancer.
