Inducing ferroptosis:A novel strategy to reverse gemcitabine resistance in pancreatic cancer
- VernacularTitle:诱导铁死亡:逆转胰腺癌对吉西他滨化疗耐药性的新策略
- Author:
Lin XIAO
1
;
Kailian ZHENG
1
;
Jiaxin ZHANG
1
;
Leshui ZHANG
1
;
Gang JIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Ferroptosis; Pancreatic Neoplasms; Drug Resistance,Neoplasm; Gemcitabine
- From: Journal of Clinical Hepatology 2025;41(7):1469-1475
- CountryChina
- Language:Chinese
- Abstract: Pancreatic cancer is a highly malignant tumor of the digestive system,with a significantly lower five-year survival rate than other malignancies.Gemcitabine(GEM)is the primary chemotherapeutic agent for pancreatic cancer,but its efficacy is often limited by chemotherapy resistance of tumor.This article elaborates on the intrinsic cellular mechanism and non-cell-autonomous mechanism of GEM resistance in pancreatic cancer and summarizes how to enhance the sensitivity of pancreatic cancer cells to GEM by inducing ferroptosis through the regulation of polyunsaturated fatty acid peroxidation,iron metabolism control,and antioxidant systems,in order to investigate the association between ferroptosis and GEM resistance mechanisms and provide new directions for the clinical treatment of pancreatic cancer.
