Exploratory study of optimal treatment plan for treatment-resistant depression
10.3760/cma.j.issn.1006-7884.2009.01.006
- VernacularTitle:难治性抑郁症优化治疗方案的研究
- Author:
Jing LI
1
;
Xiu-feng XU
;
Gang WANG
;
Cheng-ge GAO
;
Jing-ping ZHAO
;
Mo-ni TANG
;
Dan WANG
;
Bo ZHANG
;
Xue-li SUN
Author Information
1. 四川大学华西医院心理卫生中心,成都,610041
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Clinical protocols;
Antidepressive agents;
Antipsychotic agents;
Cognitive therapy;
Electroconvulsive therapy;
Optimal treatment
- From:
Chinese Journal of Psychiatry
2009;42(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimal treatment plan for treatment- resistant depression (TRD). Methods Patients who meet the inclusion and exclusion criteria were treated with different antidepressants randomly. Before the treatment, at the 1 st, 2nd, 4th, 6th week after treatment, the efficacy was evaluated with the 17-item Hamilton Rating Scale for Depression (HAMD). Results A total of 1128 subjects were enrolled, including 987 patients of non-TRD and 141 patients of TRD. At 2nd, 4th, 6th week, the HAMD scores were higher in TRD group. At 6th week after treatment, the total rates of response were 73.86% in non-TRD and 58.87% in TRD group respectively. The rates of response were 54.3%, 57.9%, 57.1%, 62.5%, 63.6% respectively in TRD patients with augmentation treatment of lithium, thyroxine, electro-convulsive treatment, atypical antipsychotics and cognitive behavioral therapy. Conclusion The treatment of antidepressant combined with lithium, thyroxine, electro-convulsive treatment, atypical antipsychotics or cognitive behavioral therapy can improve the efficacy in TRD patients.
