Protective effect of macrophage inflammatory protein-2 antibody in lung tissue of pulmonary oxygen toxicity in mice
10.3760/cma.j.issn.1009-6906.2010.03.003
- VernacularTitle:巨噬细胞炎症蛋白-2抗体对肺型氧中毒小鼠肺组织的保护作用
- Author:
Shi-feng WANG
1
;
Jia ZHU
;
Chuan-lu L(U)
;
Yang WANG
;
Yi-qun FANG
;
Wen-bo WANG
Author Information
1. 海军医学研究所,上海,200433
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Pulmonary oxygen toxicity;
Macrophage inflammatory protein-2 antibody
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2010;17(3):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of MIP-2 antibody on the inflammation in lung tissue of pulmonary oxygen toxicity in mice.Methods The pulmonary oxygen toxicity model were duplicated by breathing hyperbaric oxygen,and 40 mice were randomly divided into 5 groups:control group.0.2 MPa-224 min group,0.2 MPa-289 min group,normal O2 group,and antibody group.Mice in the control group breathed normal air,the normal O2 group breathed N2-O2 gas mixture,in which O2 partial pressure was same to that in the atmosphere.The antibody group breathed MIP-2 antibody aerosol.The expression of MIP-2 in the lung was measured by IHC.Results The MIP-2 abundance of HBO treated groups was significantly higher than that of the control group (P<0.05),whereas the expression of MIP-2 of the normal O2 group was not significantly higher than that of the control group (P>0.05).MIP-2 antibody may alleviate inflammation lesion of pulmonary oxygen toxicity in mice.Conclusions Pulmonary oxygen toxicity might elevate expression of MIP-2,and MIP-2 antibody alleviate inflammation lesion of pulmonary oxygen toxicity in mice.
