Emphasizing the diagnosis and treatment of acute severe autoimmune hepatitis
- VernacularTitle:重视对急性重症自身免疫性肝炎的诊治
- Author:
Min LIAN
1
;
Ruqi TANG
;
Xiong MA
Author Information
- Publication Type:Journal Article
- Keywords: Hepatitis,Autoimmune; Glucocorticoids; Liver Transplantation
- From: Journal of Clinical Hepatology 2025;41(7):1261-1265
- CountryChina
- Language:Chinese
- Abstract: At present,the diagnostic criteria for acute severe autoimmune hepatitis(AS-AIH)include acute onset,consistency with the diagnostic criteria for autoimmune hepatitis(AIH),presence of jaundice,and international normalized ratio≥1.5 at the time of diagnosis,without evidence of hepatic encephalopathy or previous liver disease.As a special subtype of AIH,AS-AIH is characterized by acute onset and rapid disease progression,and thus early diagnosis is of vital importance.Glucocorticoid therapy should be given as early as possible after diagnosis to prevent the progression to acute liver failure and reduce the risk of liver transplantation.Management of AS-AIH patients is challenging,since patients often lack typical clinical features and histological manifestations of AIH at the time of diagnosis,and early assessment of glucocorticoid response and a treatment regimen with proper doses are important for improving the prognosis of patients.
