Study on the correlation between urinary calcium levels and severity and prognosis of chronic kidney disease
10.3760/cma.j.cn112338-20240708-00407
- VernacularTitle:尿钙排泄量与慢性肾脏病严重程度及预后的相关性研究
- Author:
Qiongjing YUAN
1
;
Yanyun XIE
;
Jinwei WANG
;
Zhangzhe PENG
;
Pan YU
;
Ting MENG
;
Ling HUANG
;
Wei WANG
;
Xiaozhao LI
;
Hanwei HUANG
;
Fang WANG
;
Bixia GAO
;
Minghui ZHAO
;
Qiaoling ZHOU
;
Luxia ZHANG
;
Hui XU
Author Information
1. 中南大学湘雅医院肾内科，长沙 410008
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
Urinary calcium excretion;
End-stage kidney disease;
All-cause mortality;
Cardiovascular events
- From:
Chinese Journal of Epidemiology
2025;46(2):264-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between 24-hour urinary calcium (24 h UCa) level and the risk of end-stage kidney disease (ESKD), cardiovascular disease (CVD), and all-cause mortality.Methods:In the Chinese Cohort Study of Chronic Kidney Disease, we examined 3 375 patients aged 18-74 years with CKD stages 1-4. Kaplan-Meier survival and Cox proportional hazard regression models were used to test a time-to-event association between levels of 24 h UCa and incidence of ESKD, CVD, and all-cause mortality.Results:During a follow-up of 4.17 (3.37, 5.20) years, 179, 145, 104 and 38 ESKD events occurred in <0.60, 0.60-, 1.20-, ≥2.32 mmol 24 h UCa groups. Higher levels of 24 h UCa (1.20-,≥2.32 mmol) were independently associated with a lower incidence of ESKD events in patients with CKD, with HR (95% CI) of 0.71 (0.54-0.93) and 0.43 (0.29-0.64), respectively. No significant associations with CVD and all-cause mortality endpoints were detected. Conclusion:Among patients with CKD, levels of 24 h UCa displayed an association with the risk of ESKD among patients with CKD stages 1-4.
