Single nucleotide polymorphism typing of Yersinia pestis in natural plague foci around Qinghai Lake
10.3969/j.issn.1002-2694.2025.00.094
- VernacularTitle:环青海湖地区鼠疫疫源地鼠疫菌单核苷酸多态性研究
- Author:
Sheng LI
1
;
Juan JIN
;
Jian HE
;
Xiao-yan YANG
;
Ji-xiang BAI
;
You-quan XIN
;
Li ZHANG
;
Xiao-lu ZHANG
;
Wen-qi DU
;
Wei LI
Author Information
1. 青海大学医学院公共卫生系,西宁 810001;青海省地方病预防控制所鼠疫菌专业实验室,西宁 810021
- Publication Type:Journal Article
- Keywords:
Qinghai Lake region;
natural plague foci;
Yersinia pestis;
single nucleotide polymorphism(SNP)
- From:
Chinese Journal of Zoonoses
2025;41(6):592-596
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at determining the molecular characteristics of Yersinia pestis in the natural plague foci around Qinghai Lake through single nucleotide polymorphism technology,to lay a foundation for molecular epidemiological and source-tracing analysis of Y.pestis in this area.Using the whole genome sequencing technology,we obtained the whole genome sequences of 84 representative Y.pestis strains.Using the sequences of Y.pestis and Yersinia pseudotuberculosis IP32953 from the NCBI database as references,we compared and analyzed the 2 298 SNP loci of these strains.From 1957 to 2020,84 representative strains of Y.pestis from the natural plague foci around Qinghai Lake were divided into two clades:1.IN2 and 3.ANT1.The 1.IN2 clade was the characteristic population of Y.pestis throughout all epidemic years in this area.Additionally,analysis of the SNP distribution and hosts in the region indicated that the 1.IN2 clade was located in five counties except Wulan,whereas the 3.ANT1 clade was isolated from Himalayan marmot and dog in two counties.In conclusion,the population structure of SNP of Y.pestis in the natural plague foci around Qinghai Lake is relatively simple,and SNP analysis of Y.pestis provided a scientific basis for tracing plague epidemic sources and formulating plague prevention and control measures in this area.
