Current applications and future prospects of targeted chemokine CXC subfamily receptor 4 PET imaging
10.3760/cma.j.cn321828-20250107-00005
- VernacularTitle:靶向趋化因子CXC亚家族受体4 PET显像的应用现状及展望
- Author:
Xiaojing LIU
1
;
Junling XU
1
Author Information
1. 郑州大学人民医院、河南省人民医院核医学科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Receptors, CXCR4;
Positron-emission tomography;
68Ga-Pentixafor;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(10):627-631
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, targeted PET imaging of chemokine CXC subfamily receptor 4 (CXCR4) has become a prominent area of research, offering considerable potential for precise diagnosis, tracking disease progression noninvasively, guiding therapeutic strategies, and monitoring treatment responses. This article reviews recent achievements in noninvasive molecular imaging techniques targeting CXCR4 expression, with a particular focus on the pathophysiological mechanisms underlying CXCR4 and the clinical utility of the molecular probe 68Ga-pentixafor PET for diagnosis and treatment. Furthermore, the paper discusses the clinical translation of CXCR4 molecular imaging and highlights prospective research directions.
