Research progress of lactate and lactylation in cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.08.001
- VernacularTitle:乳酸及乳酸化修饰在心血管疾病中的研究进展
- Author:
Yiqing YANG
1
;
Yuyu YAO
1
;
Naifeng LIU
1
Author Information
1. 东南大学附属中大医院心血管内科,江苏省南京市 210009
- Publication Type:Journal Article
- Keywords:
lactate;
lactylation;
cardiovascular diseases
- From:
Chinese Journal of Arteriosclerosis
2025;33(8):645-654
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming plays a crucial role in the pathogenesis of cardiovascular diseases(CVD).Lactate,a metabolite of glycolysis,is now considered an important cellular signaling molecule involved in regulating various metabolic processes within the microenvironment.Recently discovered lactylation modifications have been found to play significant roles in CVD such as atherosclerosis(As),vascular or valve calcification,myocardial infarction,heart failure(HF),and pulmonary hypertension(PH).This review summarizes the regulatory mechanisms of lactate and lactylation modifications in these CVD,aiming to provide new insights for their precise prevention and treatment strategies.
